Results 111 to 120 of about 1,736,784 (299)

TGFβ1 Activates Lnc‐APUE to Promote Tumor Metastasis via the Alu Element‐Driven STAU1‐Mediated Decay of CDH1 mRNA

Advanced Science, EarlyView.
We delineate a TGFβ1/SMAD/lnc‐APUE/E‐cadherin axis wherein TGFβ1 signaling activates lnc‐APUE; lnc‐APUE subsequently downregulates E‐cadherin expression via Alu element‐driven STAU1‐mediated decay of CDH1 mRNA, thereby promoting tumor metastasis. Our findings reveal a novel regulatory function for lnc‐APUE within the SMD pathway, elucidate a distinct ...
Song‐Yang Li, Jia‐Hui Huang, Jin‐E Yang, Yi‐Hang Li, Juan‐Zhen Hong, Ting‐Ting Wang, Ying‐Lei Chi, Meng‐Zhi Wu, Wei Wang, Ying Zhu, Shi‐Mei Zhuang   +10 more
wiley   +1 more source

Crisis gelásticas originadas en lóbulo temporal

Acta Neurológica Colombiana, 2023
Las crisis gelásticas son una forma rara de epilepsia no convulsiva, más frecuente en población adulta joven y casi exclusiva de hamartomas hipotalámicos; sin embargo, hay otras localizaciones no hipotalámicas poco descritas en las cuales se presentan ...
Sergio Francisco Ramírez, Loida Camargo, Andrés Díaz Campos, Alexander Vitola, Katherine Parra, Wilson Suarez, Viviana López Ramírez   +6 more
doaj  

RENAL‐CHIP: Rejection Evaluation via Non‐Invasive Analysis of Circulating Podocytes With Herringbone‐Chip Isolation Platform

Advanced Science, EarlyView.
RENAL‐CHIP converts 1 mL of peripheral blood into a biopsy‐equivalent readout of renal‐allograft fate. By magnetic capture and release of donor‐derived circulating podocytes through a herringbone microfluidic chip, 84% capture, 96% release and single‐cell RNA evidence of rejection‐specific immunity are achieved.
Juan Song, Yilong Liu, Zeyuan Zheng, Ming Zhu, Yuning Zou, Pei Liu, Yue Zheng, Xiyuan Yu, Jianzhong Zheng, Chen Shao, Huimin Zhang, Chaoyong Yang   +11 more
wiley   +1 more source

Graphical Empirical Mode Decomposition–Convolutional Neural Network-Based Expert System for Early Corrosion Detection in Truss-Type Bridges

Infrastructures
Corrosion is a critical issue in civil structures, significantly affecting their durability and functionality. Detecting corrosion at an early stage is essential to prevent structural failures and ensure safety. This study proposes an expert system based
Alan G. Lujan-Olalde, Angel H. Rangel-Rodriguez, Andrea V. Perez-Sanchez, Martin Valtierra-Rodriguez, Jose M. Machorro-Lopez, Juan P. Amezquita-Sanchez   +5 more
doaj   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection

Advanced Science, EarlyView.
A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez, David Azorín‐Soriano, Araceli Lérida‐Viso, Jessie García‐Fleitas, Paula M Soriano‐Teruel, Jennifer Soler Beatty, Paula Rodrigo‐Martínez, Pau Arroyo, Sara Rojas‐Vázquez, Isabel Fariñas, Félix Sancenón, Juan F. Blandez, Alba García‐Fernández, Ramón Martínez‐Máñez   +13 more
wiley   +1 more source

Halving poverty in Mexico [PDF]

We estimate the required time and the minimum necessary growth rate to halve poverty incidence and poverty intensity in Mexico’s rural and urban areas for a series of counterfactual distribution and growth scenarios.
Juan Carlos Chávez-Martín del Campo, Manuel Gómez   +1 more
core  

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

GEOUNED: A new conversion tool from CAD to Monte Carlo geometry

Nuclear Engineering and Technology
The GEOUNED code is specifically designed to convert CAD models, defined using the B-rep approach, into MC radiation transport models, defined using the CSG approach, and vice versa from MC to CAD.
J.P. Catalán, P. Sauvan, J. García, J. Alguacil, F. Ogando, J. Sanz   +5 more
doaj   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source