The mechanism of pacifigorgiadiene synthase from Burkholderia gladioli was investigated through isotopic labeling experiments and DFT calculations. The results revealed an unexpected labeling pattern which appeared to be different in the main and the side products, requiring unprecedented mechanistic explanations, including a “break‐flip‐cyclise ...
Zhiyong Yin +6 more
wiley +1 more source
Chemical Ligation of Backbone N‐hydroxylated Peptides
Peptide backbone N‐hydroxylation enables sequence‐agnostic fragment ligation via hydroxamate O‐acyl capture and O→N acyl transfer in water. Broad tolerance of sterically demanding nucleophilic residues is observed, and reductive N─O cleavage restores the native amide bond.
Natalia Cano‐Sampaio +1 more
wiley +1 more source
Longitudinal changes in circulating biomarkers from baseline to week 48 in treatment-Naïve people living with HIV initiating integrase inhibitor-based antiretroviral therapy. [PDF]
Blanco JR +17 more
europepmc +1 more source
Abstract The objective of this work is to demonstrate that the inclusion of an up‐flow anaerobic sludge bed (UASB reactor) within an industrial wastewater treatment plant reduces the plant's investment and operating costs compared to a system based solely on conventional complete‐mix activated sludge (CMAS), operating under the same design principles ...
Juan Manuel Morgan‐Sagastume +1 more
wiley +1 more source
WABAD: A world annotated bird acoustic dataset for passive acoustic monitoring. [PDF]
Pérez-Granados C +101 more
europepmc +1 more source
Association of Sarcopenia with Lower Adiponectin Levels and Reduced Estimated Appendicular Lean Mass in Patients with Metabolic Syndrome: A Cross-Sectional Study. [PDF]
Suárez-Cuenca JA +17 more
europepmc +1 more source
Applying the New Inflammation Criterion Impairs GLIM Validity in Hospitalized Patients with Acute Medical Conditions. [PDF]
Fontané L +11 more
europepmc +1 more source
Solid-phase synthesis and biological evaluation of des-hydroxy pseudouridimycin analogs. [PDF]
Anwar AF +6 more
europepmc +1 more source
Annual Reports to the ESA Council ESA 110th Annual Meeting July, 2025
The Bulletin of the Ecological Society of America, EarlyView.
wiley +1 more source

