Results 191 to 200 of about 2,148,903 (315)
U.S. Equal Employment Opportunity Commission v. Candid Litho Printing, LTD dba Candid Worldwide, fka Blue Ocean Worldwide [PDF]
, 2018 Ferenbach, Judge Cam
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
EEOC v. Lexus of Serramonte, Sonic Automotive, Inc., and First America Automotive [PDF]
, 2007 Armstrong, Judge Saundra
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Diversity on the bench: An analysis of gendered biases in the language of Australian Family Law Court judgments. [PDF]
PLoS OneAkand E +4 more
europepmc +1 more source
EEOC v. Cracker Barrel Old Country Store, Incorporated [PDF]
, 2007 Vazquez, Judge Martha
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source