Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Translation and cross-cultural adaptation of the 2017 Oncology Nurse Navigator Core Competencies in Brazil. [PDF]
Cunha MLDR, Barros AS, Santos ERD.
europepmc +1 more source
Report of the committee of Judges of musical instruments [PDF]
William H. Norris +4 more
openalex +1 more source
Supreme Court of Judicature. (Common Pleas Division) (Before Lord Coleridge and a Special Jury.) Novell V. Williams. (Summing up of the Judge.—November 13, 1879.) [PDF]
openalex +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Perceived vibrato and the singing power ratio explain overall evaluations in opera singing. [PDF]
Kondo H, Kondoh S, Fujii S.
europepmc +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Using structural equation modelling to reassess bias in judging the vault event in men's artistic gymnastics. [PDF]
Fung SF, Han YS, Mickevics A.
europepmc +1 more source

