Results 21 to 30 of about 343,726 (278)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Research on Maintaining Judicial Fairness: Institutional Innovation and Practical Exploration [PDF]

open access: yesSHS Web of Conferences
With society’s rapid development and changes, maintaining judicial fairness has become a core issue in the judicial system and practice. Realizing judicial justice is related to the correct implementation of the law and the cornerstone of maintaining ...
Chon Ao Ieong Man
doaj   +1 more source

Assisting and advising the sentencing decision process : the pursuit of 'quality' in pre-sentence reports [PDF]

open access: yes, 2008
Pre-sentence reports are an increasingly prevalent feature of the sentencing process. Yet, although judges have been surveyed about their general views, we know relatively little about how such reports are read and interpreted by judges considering ...
Burns, Nicola   +4 more
core   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

open access: yesFEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart   +4 more
wiley   +1 more source

The myth of ‘Judicial customary law’: Reflections from Anglophone Cameroon

open access: yesInkanyiso, 2020
This paper unravels the origins of the concept of ‘judicial customary law’, a variant of customary law, acknowledged and recognised in some common law jurisdictions of sub-Saharan Africa.
Emmanuel M. Kiye
doaj   +1 more source

\u3ci\u3eChevron\u3c/i\u3e Without the Courts? The Supreme Court\u27s Recent \u3cem\u3eChevron\u3c/em\u3e Jurisprudence Through an Immigration Lens [PDF]

open access: yes, 2012
The limits of administrative law are undergoing a seismic shift in the immigration arena. Chevron divides interpretive and decision-making authority between the federal courts and agencies in each of two steps.
Rana, Shruti
core   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

open access: yesAging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath   +3 more
wiley   +1 more source

Judicial Performance and Experiences of Judicial Work: Findings from Socio-legal Research

open access: yesOñati Socio-Legal Series, 2014
Judicial performance evaluation processes and programs tend to imply an abstract, normative model of the proper judge. The focus is on the individual judicial officer, identifying how judges ought to perform their judicial work and assessing any ...
Sharyn Roach Anleu, Kathy Mack
doaj   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

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