Results 161 to 170 of about 408,951 (301)

Social Work Workforce, Licensing, and Hawai'i: An Overview. [PDF]

open access: yesHawaii J Health Soc Welf
Arndt RG   +3 more
europepmc   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi   +6 more
wiley   +1 more source

Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly

open access: yesAdvanced Science, EarlyView.
The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu   +8 more
wiley   +1 more source

Judicial demands for prostate cancer treatment in Brazil: androgen receptor pathway inhibitors are an urgent public health problem. [PDF]

open access: yesEinstein (Sao Paulo)
Silveira MAD   +8 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang   +12 more
wiley   +1 more source

Tailored Organogel Systems for Optimized Pesticide Delivery: Mechanistic Insights and Agricultural Applications

open access: yesAdvanced Science, EarlyView.
Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang   +6 more
wiley   +1 more source

A systematical procedure to extracting legal entities from Indonesian judicial decisions. [PDF]

open access: yesMethodsX
Nuranti EQ   +4 more
europepmc   +1 more source

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