Results 61 to 70 of about 592,432 (315)

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Venous Ectasia of Retromandibular and Common Facial Veins: A Rare Clinical Entity

Turkish Archives of Otorhinolaryngology, 2020
Venous ectasias are benign conditions of the neck, in which focal dilatations of veins occur. Internal jugular, external jugular or superficial veins are usually the affected ones in the neck. They are often ignored or misdiagnosed. Here we are reporting
Darwin Kaushal, Nithin Prakasan Nair, Amit Goyal, Vidhu Sharma, Vishudh Mohan   +4 more
doaj   +1 more source

Giant Extracranial Aneurysms of Both Internal Carotid Arteries with Aberrant Jugular Veins in a Patient with Neurofibromatosis Type 1

American Journal of Neuroradiology, 2008
SUMMARY: Although neurofibromatosis type 1 (NF-1) is commonly considered neurocutaneous, severe arterial and venous abnormalities have been noted. Our patient, a 28-year-old woman, had bilateral giant extracranial aneurysms of the internal carotid ...
Y. Ku, H-W Chen, H.-Wen Chen, C. Fu, S. Chin, Y-C. Liu   +5 more
semanticscholar   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Gene Transfer of Calcitonin Gene-Related Peptide Inhibits Macrophages and Inflammatory Mediators in Vein Graft Disease [PDF]

, 2008
Vein graft disease is a chronic inflammatory disease and limits the late results of coronary revascularization. Calcitonin gene-related peptide (CGRP) inhibits macrophages infiltrated and inflammatory mediators, we hypothesized that transfected CGRP gene
Hongsui Wu, Huanxin Yang, Jian Su, Jian Zhuang, Jianguang Chen, Shiliang Chen, Xiaoning Zhang, Yuhui Zheng, Zhihong Chen   +8 more
core   +1 more source

An anatomy-based lumped parameter model of cerebrospinal venous circulation: can an extracranial anatomical change impact intracranial hemodynamics? [PDF]

, 2015
Background The relationship between extracranial venous system abnormalities and central nervous system disorders has been recently theorized. In this paper we delve into this hypothesis by modeling the venous drainage in brain and spinal column areas
A Caiazzo, AL Rhoton Jr, Alberto Redaelli, Antonello Barberio, B Schaller, B Schlesinger, C Beggs, C Cejas, C Magnano, CB Beggs, CB Beggs, CP Chung, CP Chung, CP Chung, CP Chung, CP Chung, CY Cheng, DG Talbert, Emiliano Votta, F Alper, F Doepp, F Doepp, F Schelling, F Sisini, G Ciuti, G Comi, G Gadda, Gianfranco Beniamino Fiore, HK Park, HY Hsu, J Gisolf, JM Valdueza, JP Mynard, K Ambarki, K Dolic, K Dolic, K Saiki, Lara Marchetti, M Bergsneider, M D'haeseleer, M Simka, M Ursino, M Zaniewski, Maria Marcella Laganà, MM Laganà, NR Mehta, P Gideon, P Lochner, P Zamboni, P Zamboni, P Zamboni, P Zamboni, Pietro Cecconi, R Manara, R Zivadinov, R Zivadinov, R Zivadinov, S Bastianello, S Stoquart-Elsankari, SC Beards, SC Shadden, SM Iencean, Stefania Marcotti, Stefano Viotti, WD Lakin, X Wu, YI Cho   +66 more
core   +2 more sources

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, EarlyView.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Comparison of Freestyle Optium Neo H and Centrivet GK Device in the Diagnosis of Hypoglycaemia and Hyperketonaemia in Dairy Goats: A Field Study

Veterinary Medicine and Science
Background There is a lack of data on the validation and diagnostic performance of the Freestyle Optium Neo‐H (Freestyle) and Centrivet GK (Centrivet) devices for the diagnosis of hypoglycaemia, hyperglycaemia and hyperketonaemia in goats. Objectives The
Murat Uztimür, Cennet Nur Ünal, Abdülkerim Deniz, Aytaç Pekmezci   +3 more
doaj   +1 more source

Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]

, 1984
The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Damsma, G.,, Gugten, J. van der,, Luiten, P.G.M.,, Steffens, A.B.,   +3 more
core   +1 more source

Design, Control, and Clinical Applications of Magnetic Actuation Systems: Challenges and Opportunities

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This review aims to provide a broad understanding for interdisciplinary researchers in engineering and clinical applications. It addresses the development and control of magnetic actuation systems (MASs) in clinical surgeries and their revolutionary effects in multiple clinical applications.
Yingxin Huo, Lidong Yang, Tiantian Xu, Dong Sun   +3 more
wiley   +1 more source