Results 61 to 70 of about 928,276 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Dynamics of a methane hydrophobe in aqueous choline chloride solution: Insights from molecular dynamics simulations

open access: yesChemical Physics Impact, 2023
Motion of hydrophobic moieties in solvent plays a crucial role in biomolecular functioning and is strongly influenced by the properties of the surrounding environment.
Pooja Nanavare   +3 more
doaj   +1 more source

Pricing power derivatives: a two-factor jump-diffusion approach [PDF]

open access: yes, 2003
We propose a two-factor jump-diffusion model with seasonality for the valuation of electricity future contracts. The model we propose is an extension of Schwartz and Smith (Management Science, 2000) and Lucia and Schwartz (Review of Derivatives Research,
Pablo Villaplana   +2 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Adaptive diffusion strategies with Markov jump over networks

open access: yesSystems Science & Control Engineering, 2020
The switching of node status on the network is a common natural phenomenon. In this paper, we study the problem of adaptive diffusion strategies with Markov jump.
Yonggang Ma, Junmei Liu
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Dynamics of a Stochastic COVID-19 Epidemic Model with Jump-Diffusion [PDF]

open access: yesAdv Differ Equ, 2021
Tesfay A   +5 more
europepmc   +2 more sources

Insight into understanding the jump frequency of diffusion in solids

open access: yesAIP Advances, 2020
In view of the diversity and ambiguity of the interpretation of the physical nature contributing to the jump frequency of diffusion in solids, the fundamental of jump frequency is reexamined with special attention toward enthalpy and entropy aspects. The
Tsang-Tse Fang   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

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