Results 131 to 140 of about 1,337,805 (372)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Analysis of Dry Wheat Yield Trend using Drought Identification Indicators in North Khorasan Province [PDF]
مطالعات جغرافیایی مناطق خشکAim: Understanding the impact of drought on agricultural yields is a pivotal concern in food security. Consequently, this study utilized the drought identification index (RDI) and the effective drought identification index (eRDI), which integrates ...
Mehdi Teimouri, Saviz Sadeghi
doaj +1 more source
Closure to “The Hydraulic Jump at an Abrupt Drop” [PDF]
, 1959 Walter L. Moore, Carl W. Morgan
openalex +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
BIOMECHANICS OF FLIGHT PHASE WHEN RUNNING LONG JUMP FROM PLACE OF DIFFERENT QUALIFICATION SPORTSMEN
Бюллетень сибирской медицины, 2014 Biomechanical features of flight phase when running long jump from place of different qualification sportsmen were investigated by method of Motion Tracking.
A. V. Razuvanova +3 more
doaj +1 more source
Notes on the Meadow Jumping Mouse (Zapus Hudsonius) Especially Regarding Hibernation [PDF]
, 1914 Harold L. Babcock
openalex +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source