Results 171 to 180 of about 1,199,966 (344)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

(Re)Considering the jump scare in four elements. [PDF]

Front Psychol
Acosta EAM, Sears DRW.
europepmc   +1 more source

Statics, dynamics, and bungee jumping [PDF]

, 2016
Cormac Flynn
openalex  

Jumping generations

Krisis | Journal for Contemporary Philosophy, 2006
openaire   +2 more sources

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Deceptive Caffeine Shows Limited Impact on Short-Term Neuromuscular Performance. [PDF]

Nutrients
Valero F, Viudez CJ, Calle S, González-Mohíno F, Salinero JJ.   +4 more
europepmc   +1 more source

Kinematic and Kinetic Risk Factors Exist Bilaterally During the First and Second Landing of the Drop Vertical Jump in Adolescent Patients following ACL Reconstruction [PDF]

Katie Sloma, Ashley Erdman, Andrew Davis, Alex Loewen, Henry Ellis, Philip Wilson, Sophia Ulman   +6 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster. [PDF]

Transl Psychiatry
Viragh E, Asztalos L, Fenckova M, Szlanka T, Gyorgypal Z, Kovacs K, IntHout J, Cizek P, Konda M, Konda-Szucs E, Zvara A, Biro J, Csapo E, Lukacsovich T, Steinbach G, Hegedus Z, Puskas L, Schenck A, Asztalos Z.   +18 more
europepmc   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source