Results 191 to 200 of about 116,517 (298)

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

open access: yesAdvanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song   +24 more
wiley   +1 more source

Massively parallel jumping assay decodes Alu retrotransposition activity. [PDF]

open access: yesNat Commun
Matharu N   +12 more
europepmc   +1 more source

NIR Driven Pd/Cerium Oxide Nano‐Heterojunction for Enhanced Salvaging Sepsis Induced Acute Liver Injury via Reprogramming Redox Homeostasis in Synergy with Inducing Autophagy

open access: yesAdvanced Science, EarlyView.
In vivo SALI therapy is achieved by scavenging intracellular ROS levels, downregulating inflammatory factors expression levels, inducing macrophage M2 directional polarization, and activating Keap1/Nrf‐2/HO‐1 pathway to reprogram redox homeostasis, induce cellular autophagy, reduce systemic inflammation, and promote liver tissue repair. Abstract Sepsis
Tao Qin   +21 more
wiley   +1 more source

Spontaneous Strain‐Spin Transition Coupling Molecular Crystal with Thermal Magnetic Memory Effect, Anisotropic High‐κ and Switchable Dielectric Permittivity

open access: yesAdvanced Science, EarlyView.
A radical salt undergoes a paraelastic‐ferroelastic phase transition, which is coupled with spin‐Peierls transition, resulting in it integrating self‐strain, spin bistability, switchable dielectric and high‐ properties. Abstract Materials that exhibit controllable changes in electrical, magnetic, or spontaneous strain properties, particularly those ...
Xuan‐Rong Chen   +5 more
wiley   +1 more source

Optimal estimation for discrete time jump processes [PDF]

open access: green, 1978
María Coronado Vaca, Steven A. Tretter
openalex   +1 more source

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