Results 141 to 150 of about 686,503 (253)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

open access: yesAdvanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo   +11 more
wiley   +1 more source

Geistliche Tugend- und Sitten-Lehre

open access: yes
Vorlageform des Erscheinungsvermerks: Franckfurth und Leipzig, Bey den Zunnerischen Erben und Johann Adam Jung ...
Pritius, Johann Georg
core   +1 more source

Electron‐Beam Enables Spatially Resolved Defect‐Mediated Work Function Modulation in FAPbI3 Perovskite Thin Films

open access: yesAdvanced Science, EarlyView.
Electron‐beam irradiation enables defect‐mediated work function modulation in metal halide perovskites by regulating interstitial iodides. This approach allows continuous Fermi‐level tuning and spatially resolved formation of lateral surface‐potential‐defined junctions with built‐in potential.
Hyeonho Park   +9 more
wiley   +1 more source

Defect‐Engineered LiYO2 Interlayers Enabling Fast Interfacial Li+ Transport in All‐Solid‐State Batteries

open access: yesAdvanced Science, EarlyView.
Defect‐engineered LiYO2 interlayers are designed through aliovalent Zn2+ and Zr4+ substitution to regulate Li+ point‐defect chemistry in Ni‐rich cathodes. Compared with Li‐excess‐type LYZnO, Li‐vacancy‐type LYZrO enables faster Li+ transport, suppresses Li6PS5Cl decomposition, lowers interfacial resistance, and mitigates polarization growth, thereby ...
Sodam Kim   +6 more
wiley   +1 more source

Notas para una reformulación de la epistemología junguiana. Segunda Parte

open access: yesRevista de Psicología
La obra junguiana, que posee múltiples fuentes y cuyo carácter innovador conmueve la cosmovisión científica y cultural vigente, requiere ser comprendida desde sus propios términos. Se intenta recuperar, más allá de sus aparentes vacilaciones, la unidad
Bernardo Nante
doaj  

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