Results 1 to 10 of about 83,399 (138)

Multi-state catch bond formed in the Izumo1:Juno complex that initiates human fertilization [PDF]

Nature Communications
Izumo1:Juno-mediated adhesion between sperm and egg cells is essential for mammalian sexual reproduction. However, conventional biophysical and structural approaches have provided only limited functional insights.
Sean Boult, Paulina Pacak, Byeongseon Yang, Haipei Liu, Viola Vogel, Michael A. Nash   +5 more
doaj   +2 more sources

Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization

Nature Communications, 2016
Sperm-egg fusion requires the interaction between IZUMO1 on the sperm and JUNO on the egg. Here, the authors report the crystal structure of mouse JUNO, and use it to explain its lack of binding to folate, along with in vivofunctional analyses.
Yuhkoh Satouh, Yoshitaka Fujihara, Masahito Ikawa   +2 more
exaly   +2 more sources

Responses of three nesting sea turtle species to hard-armoring structures

Frontiers in Marine Science, 2022
In the face of modern challenges, analyzing sea turtle nesting trends is critical to better understand impacts to these vulnerable species. The introduction of hard-armoring structures (e.g., seawalls, rock revetments) on sea turtle nesting beaches poses
Sarah E. Hirsch, Madison Toonder, Madison Toonder, Jennifer D. Reilly, Shelby R. Hoover, Justin R. Perrault   +5 more
doaj   +1 more source

Next generation automated traceless cell chromatography platform for GMP-compliant cell isolation and activation

Scientific Reports, 2022
Large-scale target cell isolation from patient blood preparations is one of the critical operations during drug product manufacturing for personalized cell therapy in immuno-oncology.
Sabine Radisch, Mateusz P. Poltorak, Michaela Wagner, Vlad Cletiu, Christian Radisch, Irina Treise, Steffi Pann, Alexis Weigt, Sophie Artner, Stefan Dreher, Fabian Fechner, Bojana Borjan, Simon P. Fraessle, Manuel Effenberger, Eileen Benke, Gottfried Navratil, Norbert Hentschel, Dirk H. Busch, Thomas Schmidt, Christian Stemberger, Lothar Germeroth   +20 more
doaj   +1 more source

Activation-inducible CAR expression enables precise control over engineered CAR T cell function

Communications Biology, 2023
CAR T cell therapy is a rapidly growing area of oncological treatments having a potential of becoming standard care for multiple indications. Coincidently, CRISPR/Cas gene-editing technology is entering next-generation CAR T cell product manufacturing ...
Simon P. Fraessle, Claudia Tschulik, Manuel Effenberger, Vlad Cletiu, Maria Gerget, Kilian Schober, Dirk H. Busch, Lothar Germeroth, Christian Stemberger, Mateusz P. Poltorak   +9 more
doaj   +1 more source

Dirac-based solutions for JUNO production system [PDF]

EPJ Web of Conferences, 2020
The JUNO (Jiangmen Underground Neutrino Observatory) Monte Carlo production tasks are composed of complicated workflow and dataflow linked by data.
Zhang Xiaomei
doaj   +1 more source

Evaluating prevalence of external injuries on nesting loggerhead sea turtles Caretta caretta in southeastern Florida, USA

Endangered Species Research, 2021
Sea turtles face both anthropogenic and natural threats including boat strikes, fisheries, pollution, and predator attacks. Injuries from anthropogenic sources are more common than naturally caused injuries.
A Ataman, AM Gainsbury, CA Manire, SL Hoffmann, A Page-Karjian, SE Hirsch, MMR Polyak, DL Cassill, DM Aoki, KM Fraser, S Klingshirn, JA Stoll, JR Perrault   +12 more
doaj   +1 more source

Plasma Observations During the 7 June 2021 Ganymede Flyby From the Jovian Auroral Distributions Experiment (JADE) on Juno

Geophysical Research Letters, 2022
We report on plasma observations from Juno/Jovian Auroral Distributions Experiment during the Ganymede flyby on 7 June 2021. Juno approached Ganymede from southern latitudes, passed through the wake region, then through its magnetosphere to closest ...
F. Allegrini, F. Bagenal, R. W. Ebert, P. Louarn, D. J. McComas, J. R. Szalay, P. Valek, R. Wilson, S. J. Bolton, J. E. P. Connerney, G. Clark, S. Duling, W. S. Kurth, B. Mauk, J. Saur, J. H. Waite   +15 more
doaj   +1 more source

Juno and CD9 protein network organization in oolemma of mouse oocyte

Frontiers in Cell and Developmental Biology, 2023
Juno and CD9 protein, expressed in oolemma, are known to be essential for sperm-oocyte binding and fusion. Although evidence exists that these two proteins cooperate, their interaction has not yet been demonstrated.
Michaela Frolikova, Vishma Pratap Sur, Ivan Novotny, Michaela Blazikova, Jana Vondrakova, Ondrej Simonik, Lukas Ded, Eliska Valaskova, Lenka Koptasikova, Ales Benda, Pavla Postlerova, Pavla Postlerova, Ondrej Horvath, Katerina Komrskova, Katerina Komrskova   +14 more
doaj   +1 more source

Структурные особенности вегетативных органов некоторых видов рода Iris L., произрастающих в Узбекистане

Turczaninowia, 2020
Впервые изучено морфо-анатомическое строение вегетативных органов десяти видов, относящихся к четырем секциям и трем подродам рода Iris L.: I. alberti Regel – из секции Iris (подрод Iris), I. korolkowii Regel и I. stolonifera Maxim. – из секции Hexapogon
Наргиза Камилжановна Рахимова, Гулжан Мадримбаевна Дусчанова, А.Т. Абдуллаева   +2 more
doaj   +1 more source