Results 51 to 60 of about 263,006 (329)
Memory, history and oblivion in Horrelpoot by Eben Venter
Literator, 2008 “Horrelpoot” by Eben Venter joins the ranks of other postapartheid Afrikaans literature that reflects different sides of memory, history and guilt. This article explores the different constructs of memory – laced with rich Jungian archetypal images ...
M. Postma, M.N. Slabbert
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FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
On the Centrality of Jurisprudence [PDF]
The American Journal of Jurisprudence, 2019 Political communities typically organise themselves by an appeal to values. Sometimes the values invoked are abstract ideas such as justice or equality. One such idea is that of law. In many important instances, practices cannot be understood except by reference to the values to which they make an implicit appeal but from which they fall short; and ...
openaire +3 more sources
FEBS Letters, EarlyView.Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Aquamation: legal nail in burial and cremation’s coffin?
De Jure, 2021 Respect for the dead defines a community. Burial of a corpse has for many years been the only way of disposing of a dead body. Land available for burial sites is limited. In the 1960s cremation became an acceptable alternative to burial.
Magda Slabbert, Melody Labuschaigne
doaj
FEBS Open Bio, EarlyView.Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti +8 more
wiley +1 more source
The Role of History in the Process of Jurisprudential Inference with the Emphasis on the Discovery of Tradition and Jurisprudential Decree [PDF]
تاریخ اسلامOne of the important areas of emerging jurisprudential debates is the investigation of the role of history in jurisprudence with an emphasis on questions about the how of discovering the tradition and the origin of issuing jurisprudential decree. In this
Seyied Mahdi Mohammadi
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