Results 211 to 220 of about 62,486 (251)
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Colloids and Surfaces B: Biointerfaces, 2022
Mechanical properties play key roles in the immune system, especially the activation, transformation and subsequent effector responses of immune cells. As transmembrane adhesion receptors, integrins mediate the adhesion events of both cells and cell-extracellular matrix (ECM).
Leqian, Zhao +3 more
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Mechanical properties play key roles in the immune system, especially the activation, transformation and subsequent effector responses of immune cells. As transmembrane adhesion receptors, integrins mediate the adhesion events of both cells and cell-extracellular matrix (ECM).
Leqian, Zhao +3 more
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Thallium Induces Apoptosis in Jurkat Cells
Annals of the New York Academy of Sciences, 2003Abstract: Thallium induces swelling in mitochondria and apoptosis in Jurkat cells. Both the swelling and the apoptosis are inhibited by means of cyclosporine A (CsA), thus suggesting that these phenomena result from the opening of the membrane transition pore (MTP) in mitochondria. Therefore, apoptosis can be explained as due to the opening of the MTP
BRAGADIN M. +4 more
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Identification of GATA3 binding sites in Jurkat cells
Gene, 2009Determining binding sites of transcription factors is important for understanding the transcriptional control of target genes. Although a transcription factor GATA3 plays a pivotal role in Th2 lymphocyte development, its physiological role is not clearly defined because the target genes remain largely unknown.
Masahiro, Okazaki +4 more
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Inhibition of calcineurin by quercetin in vitro and in Jurkat cells
Journal of Biochemistry, 2009Calcineurin (CN), the Ca(2+)/calmodulin (CaM)-dependant protein phosphatase, is an integral enzyme involved in activation of T cells. It is also the target of various inhibitors such as cyclosporine A (CsA) and FK506 both of which have been widely used as immunosuppressants.
Hu, Wang +3 more
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Aloin induces apoptosis in Jurkat cells
Toxicology in Vitro, 2008Aloe is widely used as a dietary supplement. However, there are continuing concerns over the toxicity and the purity of aloe-based products. The primary class of compounds responsible for aloe-induced toxicity are anthraquinones. One of these, aloe-emodin, has been extensively investigated for apoptosis inducing effects.
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Differential characteristics of CD133+ and CD133− Jurkat cells
In Vitro Cellular & Developmental Biology - Animal, 2015T cell acute lymphoblastic leukemia (T-ALL) is a hematological disease including malignancy of T cell precursors. There are some T-ALL patients that are drug-resistant. A major cause of treatment failure in cancers can be associated with the existence of cancer stem cells.
Azadeh, Anbarlou +5 more
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Phototoxicity and cytotoxicity of chlorophyll a/cyclodextrins complexes on Jurkat cells
Bioelectrochemistry, 2008The aggregation status of chlorophyll a (Chl a) and the ability of four cyclodextrins, hydroxypropyl-beta-cyclodextrin (HP-beta-CD), hydroxypropyl-gamma-cyclodextrin (HP-gamma-CD), heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DIMEB), and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (TRIMEB), to solubilize the pigment in the complete cellular medium ...
COSMA PINALYSA +7 more
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CD25 expression on the surface of Jurkat cells
Cell and Tissue Biology, 2015Expression of the α-subunit of the interleukin-2 receptor (IL-2Rα) was assessed by quantifying CD25 upregulation in the Jurkat cell line (human acute T cell leukemia). It was found that phytohemagglutinin (PHA, 5 μmL) or PHA in combination with 12,13-phorbol dibutirate (PDBu, 10–8 M) increased the number of CD25-positive cells in the proliferating ...
A. N. Shatrova +3 more
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Models of Anergy in the Human Jurkat T Cell Line
ASSAY and Drug Development Technologies, 2003We investigated two model systems to study anergy in a human T cell line. OKT3 or calcium ionophore stimulation of Jurkat cells, in the absence of costimulation, resulted in a steep reduction in the transcription and secretion of IL-2 in response to subsequent stimulation via CD3 and CD28.
Christopher J, Howe +5 more
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Calmodulin regulation of Ca2+ entry in Jurkat T cells
Cell Calcium, 1998We have previously proposed a role for calmodulin (CaM) in the regulation of initiation of Ca2+ entry in Jurkat T cells, as well as in the regulation of the current that mediates Ca2+ entry, IT. In this report, we provide evidence for the mechanism of CaM action.
D M, Haverstick +2 more
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