Results 81 to 90 of about 74,947 (289)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Tras los concursos Behind the competitions
ARQ, 2007 Los concursos de arquitectura parecen entregar garantías de la calidad del resultado, pueden promover a arquitectos jóvenes y evidencian las tensiones arquitectónicas presentes en un momento dado.
Fernando Pérez Oyarzun
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Your guide to jury service : an obligation and an honor. Revised to 2015: Feb.
, 2011 Rev. 7/11.; Title from cover.; "State of Connecticut Judicial Branch, Jury Administrator"--Back cover.; Previously issued: Your guide to jury duty : an obligation and an honor. [Hartford] : State of Connecticut Judicial Branch, [2007].; "JDP-JA-5"--Back
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JUDGES’ EVALUATION OF ROUTINES IN MEN ARTISTIC GYMNASTICS
Science of Gymnastics Journal, 2010 For competition judging, the practice of assigning gymnastics judges into one of two groups (D-Jury and E-Jury) is internationally accepted. International judges (the highest level) are placed in the D-Jury and national judges are allocated to the E ...
George Dallas, Paschalis Kirialanis
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
On a Three-Alternative Condorcet Jury Theorem [PDF]
We investigate whether the simple plurality rule aggregates information efficiently in a large election with three alternatives. The environment is the same as in the Condorcet Jury Theorem (Condorcet (1785)).
Francois Maniquet, Johanna Goertz
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The Effect of Jury Experience on Jury Verdicts
American Review of Politics, 1982 This study considers the hypothesis that juries with more experience are more likely to convict a defendant than less experienced juries are. The theory, which has wide support among prosecutors and defense attorneys, is tested by taking all the jury trials in the Sixth Judicial District in Arkansas for the years 1978 and 1979, identifying juries with ...
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source