Results 121 to 130 of about 390,765 (298)
Reexamining the Seventh Amendment Argument Against Issue Certification [PDF]
, 2014 Issue certification does not run afoul of the Seventh Amendment because of the constitutional doctrines of standing and ripeness. Part II(A) and II(B) examines FRCP 23 and the history of class actions and issue certifications.
Aminpour, Leila +2 more
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Larry Laudan, the Pursuit of Truth, and the Meaninglessness of Burdens of Persuasion
Quaestio FactiInspired by the work of Larry Laudan, the meaninglessness of current conventional understandings and discussions of burdens of persuasion is demonstrated.
Ron Allen
doaj +1 more source
Contaminating the Verdict: The Problem of Juror Misconduct [PDF]
, 2004 This article describes the myriad ways in which misconduct by jurors can contaminate a trial and verdict and the ability of courts to remedy such misconduct.
Gershman, Bennett L.
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Jury Nullifications and the Bad Faith Juror
Law, Ethics and Philosophy, 2015 Jury nullification, that phenomenon whereby a jury returns a not-guilty verdict for a defendant it believes to be technically guilty of the alleged crime, is, obviously, a controversial issue.
Travis Hreno
doaj
Civil Justice Systems in Europe and the United States [PDF]
, 2009 Professor Kötz delivered the inaugural Herbert L. Bernstein Memorial Lecture in Comparative Law in 2002 and this article is based on his remarks. The article is included in the inaugural volume of CICLOPs that collects the first six Bernstein lectures ...
Kötz, Hein
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Issues of the Russian judicial system in the 1860–1880s in M.N. Katkov’s works
Вестник Тамбовского университета. Серия: Гуманитарные наукиImportance. The conservative trend in Russian social thought of the second half of the 19th century is one of the main goals of research in history science. The views analysis of one of the most prominent Russian conservatives, M.N.
S. N. Podlesnykh
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source