Results 131 to 140 of about 632,340 (320)

Improving “just-in-time, just-in-sequence” delivery in first-tier suppliers

, 2015
This research was conducted at the Barcelona School of Engineering (ETSEIB) and promoted by the Nissan factory in Barcelona. In this paper, first, the concept of synchronous manufacturing is explored. After several improvement ideas are spotted within the Nissan plant, the paper focuses on the suppliers. An intervention approach is proposed.
Bautista Valhondo, Joaquín, Fortuny Santos, Jordi   +1 more
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

From the law of the jungle to partnership? The bumpy road to new producer-supplier relations in the automotive industry. The example of a bodywork and assembly plant [PDF]

, 2000
Since around a decade, the automobile industry is undergoing a dramatic turnaround. New strategies for marketing and producing are considered as trigger pulses for the emergence of different inter-firm relations between customers and suppliers in the car
Kilper, Heiderose, Schmidt-Dilcher, Jürgen   +1 more
core  

Development of a dense SNP-based linkage map of an apple rootstock progeny using the Malus Infinium whole genome genotyping array

BMC Genomics, 2012
Background A whole-genome genotyping array has previously been developed for Malus using SNP data from 28 Malus genotypes. This array offers the prospect of high throughput genotyping and linkage map development for any given Malus progeny.
Antanaviciute Laima, Fernández-Fernández Felicidad, Jansen Johannes, Banchi Elisa, Evans Katherine M, Viola Roberto, Velasco Riccardo, Dunwell Jim M, Troggio Michela, Sargent Daniel J   +9 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Innovative Concepts for supply chain management. Analysis of the need and the development process [PDF]

The suitability of existing Supply Chain Management concepts to resolve present problems as well as to meet upcoming challenges toward Supply Chain Management are analyzed based on their degree of target achievement and degree of innovativeness ...
Gopfert, Ingrid, Wellbrock, Wanja
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Vulnerability of automotive supply chains as a result of implementing the just-in-sequence strategy

Economics of Enterprise
Supply chains in the automotive industry, due to their global nature, are constantly exposed to disruptions and interruptions caused by risk events. By utilizing various tools and modifying supply and distribution structures, supply chains in the automotive industry aim to mitigate the consequences of these risk events as efficiently as possible.
Aleksandra Anđelković, Goran Milovanović   +1 more
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source