Results 161 to 170 of about 121,183,718 (289)

Effective monitoring of online AI decision-making algorithms in just-in-time adaptive interventions. [PDF]

NPJ Digit Med
Trella AL, Ghosh S, Bonar EE, Coughlin L, Doshi-Velez F, Guo Y, Hung PY, Nahum-Shani I, Shetty V, Walton M, Yan I, Zhang KW, Murphy SA.   +12 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Exploring the Receptivity and Feasibility of Just-In-Time Support for Healthy Food Choices: Mixed-Method Insights for Adaptive Intervention Development. [PDF]

Curr Dev Nutr
Winkens LH, Sonneveld NA, Ligtenberg A, Schwarz A, Simons M.   +4 more
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Effectiveness of a just-in-time adaptive intervention for improving pain catastrophising in patients with chronic back pain: protocol for a pragmatic randomised controlled trial. [PDF]

BMJ Open
Sühs E, Atkins LA, Koeppen LS, Schmigalle P, Scholz C, Liegl G, Pryss R, Kraft R, Vogel C, Idrees AR, Kopf A, Reisshauer A, Vajkoczy P, Prasser F, Nolte S, Rose M, Obbarius A.   +16 more
europepmc   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Maximising the efficacy of in vivo exposure therapy using smartphone-assisted just-in-time adaptive intervention for anxiety disorders: study protocol for a randomised controlled trial. [PDF]

BMJ Open
Alonso-Olea I, Gual-Montolio P, Díaz-Sanahuja L, Niño-Ruiz L, Mira A, Casteleyn S, Granell C, García-Palacios A, Bretón-López J.   +8 more
europepmc   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Multimodal Personalized Mobile Health Just-in-Time Adaptive Intervention for Occupational Stress Management: Pilot Study. [PDF]

JMIR Mhealth Uhealth
Kunas B, Jung O, Schranz C, Schmoigl-Tonis M, Mehlis J, Laireiter AR.   +5 more
europepmc   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source