Results 201 to 210 of about 2,112,228 (281)

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

open access: yesAdvanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang   +8 more
wiley   +1 more source

Script or style? Analysis of the relationship between teaching scripts and supervision style. [PDF]

open access: yesPLoS One
Sader J   +6 more
europepmc   +1 more source

Stretchable Curvature Sensors for Motion Capture with Bending‐Stretching Coupling Deformation

open access: yesAdvanced Science, EarlyView.
Stretchable curvature sensors based on a wavy symmetric stacked‐layer structure (WSSLS) enable decoupled bending‐stretching detection with high linearity, repeatability, and durability. Integrated into smart gloves, the sensors achieved precise motion capture and human‐robot interaction, with slip‐simulation tests demonstrating a remarkable 93.6 ...
Tairan Wang   +9 more
wiley   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

open access: yesAdvanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du   +6 more
wiley   +1 more source

Reference‐Guided Chromosome‐by‐Chromosome de novo Assembly at Scale Using Low‐Coverage High‐Fidelity Long‐Reads with HiFiCCL

open access: yesAdvanced Science, EarlyView.
HiFiCCL, as the first assembly framework specifically designed for low‐coverage high‐fidelity reads, improves the assembly quality of existing assemblers and also enhances downstream applications such as large structural variant (SV) detection (>10 000 bp), synteny analysis, pangenome graph construction, and graph‐based individual‐specific germline SVs
Zhongjun Jiang   +9 more
wiley   +1 more source

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