Results 51 to 60 of about 2,027,583 (261)
Assessing Patron Driven Acquisition (PDA) adoption among Malaysian academic libraries
Pakistan Journal of Information Management & Libraries, 2020 This study aims to explore the adoption of the Patron Driven Acquisition (PDA) model among Malaysian academic libraries. The study ensues the continuous increase in the proportion and cost of information resources (electronic and print) coupled with the ...
Aliyu Olugbenga Yusuf +1 more
doaj
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Ingeniare: Revista Chilena de Ingeniería, 2008 This study presents a new mathematical model and a Greedy Randomized Adaptive Search Procedure (GRASP) meta-heuristic to solve the ordered cutting stock problem. The ordered cutting stock problem was recently introduced in literature.
Rodrigo Rabello Golfeto +2 more
doaj
Operator Idle Time Rectification as the Solution to Cycle Time Reduction in Oxygen Sensor Production
JIRAE (International Journal of Industrial Research and Applied Engineering), 2018 In factory works, there are systems that need to be followed in order to create a well-ordered process such that Just In Time (JIT) production can be reached. The lean manufacturing principle is one of the solutions for sustainable factory system. Within
Melvin Harsono, Joni Welman Simatupang
doaj +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Stochastic models of simple controlled systems just-in-time
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2018 We propose a new and simple approach for the mathematical description of a stochastic system that implements the well-known just-in-time principle. This principle (abbreviated JIT ) is also known as a just-in-time manufacturing or Toyota Production ...
Alexander A Butov, Anatoly A Kovalenko
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source