Results 161 to 170 of about 3,945 (185)

Identification of a new ‘TIGR’ mutation in a family with juvenile-onset primary open angle glaucoma

Ophthalmic Genetics, 1997
Positional mapping of families segregating for juvenile-onset primary open angle glaucoma (JOAG) has previously identified a locus (GLCIA) for this condition on the long arm of chromosome I. Recently, three mutations in the TIGR gene (Trabecular meshwork Inducible Gluco-corticoid Response protein) have been described in a total of ten familial, three ...
D, Stoilova, A, Child, G, Brice, R P, Crick, B W, Fleck, M, Sarfarazi   +5 more
openaire   +4 more sources

Homozygous p.G61E mutation in a consanguineous Pakistani family with co-existence of juvenile-onset open angle glaucoma and primary congenital glaucoma

Gene, 2015
Glaucoma is one of the primary causes of visual impairment and blindness in the world. It is characterized by the damage to the optic nerve head and visual field loss. Variants in CYP1B1 are the most common cause of glaucoma in different world populations.
Rasheeda, Bashir, Hafsa, Tahir, Khazeema, Yousaf, Shagufta, Naz, Sadaf, Naz   +4 more
openaire   +4 more sources

Bilateral Juvenile Onset Primary Open-Angle Glaucoma Among Keratoconus Patients

Journal of Glaucoma, 2015
To report the occurrence of juvenile open-angle glaucoma (JOAG) in patients with keratoconus.In this observational case series we report 6 eyes of 3 patients with keratoconus who had concomitant JOAG. Corneal topography, intraocular pressure, gonioscopic, and fundus findings were recorded for all the eyes.All 3 patients presented with corneal ectasia ...
Sahil, Goel, Anita, Ganger, Viney, Gupta
openaire   +2 more sources

Classifying juvenile onset primary open angle glaucoma using cluster analysis

British Journal of Ophthalmology, 2019
AimTo classify unrelated patients with juvenile onset primary open angle glaucoma (JOAG) into clinically useful phenotypes using cluster analysis.MethodsOut of the 527 unrelated patients with JOAG, the study included 414 patients who had all the phenotypic characteristics required for the study. A cluster analysis was performed to classify the patients
Shweta Birla, Dinesh Gupta, Bindu I Somarajan, Shikha Gupta, Abadh Kishore Chaurasia, Azmira Kishan, Viney Gupta   +6 more
openaire   +2 more sources

Genetic analysis of an Indian family with members affected with juvenile-onset primary open-angle glaucoma

Ophthalmic Genetics, 2004
Glaucoma is the second leading cause of blindness. In India, approximately 1.5 million people are blind due to glaucoma. Mutations in the MYOC gene located at the GLC1A locus on chromosome 1q21-q31 have been found in patients with juvenile-onset primary open-angle glaucoma (J-POAG).
Markandaya, M, Ramesh, TK, Selvaraju, V, Dorairaj, Syril K, Prakash, Ravi, Shetty, Jyoti, Kumar, A   +6 more
openaire   +2 more sources

Comparisons of Risk Factors and Visual Field Changes between Juvenile-Onset and Late-Onset Primary Open-Angle Glaucoma

Ophthalmologica, 2002
<i>Purpose:</i> To identify the differences in risk factors and visual field (VF) changes between juvenile primary open-angle glaucoma (JOAG) and late-onset chronic open-angle glaucoma (COAG). <i>Methods:</i> The demographic and presenting clinical data of 27 JOAG and 30 COAG patients were retrospectively reviewed.
Yu-Chieh, Ko, Catherine Jui-Ling, Liu, Joe Ching-Kuang, Chou, Mei-Ru, Chen, Wen-Ming, Hsu, Jorn-Hon, Liu   +5 more
openaire   +2 more sources

Long-Term Structural and Functional Outcomes of Therapy in Juvenile-Onset Primary Open-Angle Glaucoma : A Five-Year Follow-Up

Ophthalmologica, 2011
<b><i>Objective:</i></b> To evaluate long-term structural and functional changes of the optic nerve head in medically and surgically treated juvenile-onset primary open-angle glaucoma (JOAG). <b><i>Methods:</i></b> Forty-two eyes of 42 consecutive primary JOAG patients presenting between January 2000 and ...
Viney, Gupta, Mary, Ov, Aparna, Rao, Ajay, Sharma, Ramanjit, Sihota   +4 more
openaire   +2 more sources

Extent of asymmetry and unilaterality among juvenile onset primary open angle glaucoma patients.

Clinical & experimental ophthalmology, 2012
Juvenile onset open angle glaucoma (JOAG) due to its rarity is not well characterized. We aimed to assess the extent of interocular asymmetry of baseline intraocular pressure (IOP), disc morphometry and visual field defects at presentation in patients with primary JOAG.
Viney, Gupta, Shikha, Gupta, Munish, Dhawan, Ajay, Sharma, Kulwant S, Kapoor, Ramanjit, Sihota   +5 more
openaire   +1 more source

Juvenile onset primary open-angle glaucoma: three case studies and review.

Journal of the American Optometric Association, 1999
Common clinical characteristics of juvenile onset primary open-angle glaucoma (JPOAG) include increased intraocular pressure, optic nervehead damage, visual-field loss, and a normal-appearing iridocorneal angle by gonioscopy. Histologic analysis of the angle structures may show varying developmental abnormalities that are observed to be less obvious as
openaire   +1 more source

Novel TIGR/MYOC mutations in families with juvenile onset primary open angle glaucoma

2019
Mutations in the trabecular meshwork induced glucocorticoid response protein (TIGR) or myocilin (MYOC) has recently been shown to cause juvenile onset primary open angle glaucoma (JOAG). In this study, we identified two new mutations (Asp380Ala and Ser502Pro) in two British families and another (Pro370Leu) in a French-Canadian family.
Stoilova D., Child A., Brice G., Desai T., Barsoum-Homsy M., Ozdemir N., Chevrette L.   +6 more
openaire   +1 more source