Results 101 to 110 of about 999,967 (298)

Versatile CRISPR‐Cas Tools for Gene Regulation in Zebrafish via an Enhanced Q Binary System

open access: yesAdvanced Science, EarlyView.
This study introduces CRISPR‐Q, a transgenic CRISPR‐Cas system leveraging the QFvpr/QUAS binary expression platform in zebrafish. CRISPR‐Q overcomes previous challenges in achieving stable and efficient gene regulation. By enabling precise spatiotemporal control of transcript knockdown (CRISPR‐QKD) and gene activation (CRISPR‐Qa), it provides a ...
Miaoyuan Shi   +13 more
wiley   +1 more source

Juvenile Justice, Sullivan, and Graham: How the Supreme Court’s Decision Will Change the Neuroscience Debate [PDF]

open access: yes, 2010
Over the past twenty years, neuroscientists have discovered that brain maturation continues through an individual’s mid-twenties. The United States Supreme Court cited this research to support its abolition of the juvenile death penalty in Roper v ...
Jennings, Johanna Cooper
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

open access: yesAdvanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang   +7 more
wiley   +1 more source

Regulation of the juvenile hormone titre in the Colorado potato beetle [PDF]

open access: yes, 1978
Three main topics were investigated in regulation of the titre of juvenile hormone in haemolymph of the Colorado potato beetle ( Leptinotarsa decemlineata Say): enzymic breakdown of the hormone; binding and protection of the hormone by carrier proteins ...
Kramer, S.J.
core   +1 more source

A new female-like morph of juvenile male Levant Sparrowhawk (Accipiter brevipes) – Sexual mimicry to avoid intra-specific predation? [PDF]

open access: yes, 2015
In migrant Levant Sparrowhawk (Accipiter brevipes) at Eilat, Israel, we noted that juvenile males had two different morphs – the one described to date in literature; and a second, previously undescribed morph, with femalelike barring on the ...
Fornasari, Lorenzo, Yosef, Reuven
core   +3 more sources

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

open access: yesAdvanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen   +8 more
wiley   +1 more source

Leptin Levels are Associated with Subclinical Cardiac Dysfunction in Obese Adolescents

open access: yesDiabetes, Metabolic Syndrome and Obesity, 2020
Thamonwan Imerbtham,1 Piyanuch Thitiwuthikiat,1 Jirapas Jongjitwimol,2 Teonchit Nuamchit,1 Teerapat Yingchoncharoen,3 Duangduan Siriwittayawan1 1Department of Cardio-Thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok,
Imerbtham T   +5 more
doaj  

Louisiana Juvenile Justice at the Crossroads [PDF]

open access: yes, 1991
Over the past decade, interest in community-based corrections for juveniles has grown while dissatisfaction with the expense and ineffectiveness of training schools has increased. Since 1985, the National Council on Crime and Delinquency has investigated
Barry Krisberg   +2 more
core  

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

open access: yesAdvanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh   +11 more
wiley   +1 more source

Occurrence and Behavior of Juvenile Red Snapper, Lutjanus campechanus, on Commercial Shrimp Fishing Grounds in the Northeastern Gulf of Mexico [PDF]

open access: yes, 1994
Red snapper, Lutjanus campechanus, is subject to significant overfishing in U.S. Gulf of Mexico waters, and regulations are being implemented to reduce fishing mortality and restore them to a 20% spawning potential ratio by the year 2009.
Foster, Daniel G., Workman, Ian K.
core  

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