Results 281 to 290 of about 1,123,097 (347)

Alu Overexpression Leads to an Increased Double‐Stranded RNA Signature in Dermatomyositis

Arthritis &Rheumatology, EarlyView.
Objective Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the noncoding genome in disease pathogenesis.
Rayan Najjar, Andrew Mammen, Tomas Mustelin   +2 more
wiley   +1 more source

Efficacy and safety of tofacitinib treatment in Finnish patients with juvenile idiopathic arthritis: a real-life study. [PDF]

Arthritis Res Ther
Levälampi T, Rebane K, Mikola K, Kautiainen H, Aalto K.   +4 more
europepmc   +1 more source

Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome

Arthritis &Rheumatology, EarlyView.
Serum cytokine profiling was performed using Luminex (48 cytokines) and ELISA (5 cytokines). Assessment of key cytokines (IFN‐α, IL‐18, IL‐6, CXCL9) delineated five dominant inflammatory patterns: I, IFN‐α–dominant CSS; II, IL‐18–dominant CSS; III, IL‐6–dominant CSS; IV, IFN‐γ–dominant CSS; and V, IL‐6 & IFN‐γ intermediate CSS.
Shuya Kaneko, Maho Hatano, Asami Shimbo, Futaba Miyaoka, Hitoshi Irabu, Yuko Akutsu, Yuko Hayashi, Mao Mizuta, Yasuo Nakagishi, Keiji Akamine, Naomi Iwata, Kenji Furuno, Takayuki Tanaka, Kazuyuki Ueno, Shuhei Fujita, Koji Yokoyama, Toshinori Minato, Kazushi Izawa, Takahiro Yasumi, Tadashi Matsubayashi, Tadashi Hosoya, Hiroki Nishikawa, Junya Fujimura, Ryoko Asano, Yuko Sugita, Kenichi Watanabe, Anna Kobayashi, Takuya Endo, Katsuhide Eguchi, Ryuta Nishikomori, Ryuhei Yasuoka, Takaki Asano, Miyako Kanno, Kazuya Hamada, Yuji Fujita, Daisuke Hayashi, Shojiro Watanabe, Takeshi Shiba, Shinsuke Yasuda, Masaaki Mori, Hirokazu Kanegane, Masatoshi Takagi, Masaki Shimizu   +42 more
wiley   +1 more source

Growth and Developmental Processes Alternate During Larval Development of Atlantic Herring. [PDF]

Evol Dev
Fischbach V, Franz GP, Moritz T, Ohde D, Thieme P, Kotterba P, Polte P, Grunow B.   +7 more
europepmc   +1 more source

Effect of time to start of biologic therapy on treatment response in childhood arthritis: Results from the UCAN CAN‐DU study

Arthritis &Rheumatology, Accepted Article.
Objective To estimate the effect of time from symptom onset to start of biologic treatment on achieving inactive arthritis within six months in a cohort of juvenile idiopathic arthritis (JIA) patients. Methods The international UCAN CAN‐DU study prospectively enrolls JIA patients across Canada and the Netherlands.
Jelleke B. de Jonge, Sytze de Roock, Dieneke Schonenberg‐Meinema, J. Merlijn van den Berg, Deborah A. Marshall, Sebastiaan J. Vastert, Rae S.M. Yeung, Joost F. Swart, Susanne M. Benseler, The UCAN CAN‐DU and UCAN CURE consortia, Adam Huber, Alan Rosenberg, Alexander Mosoiu, Alisa Rachlis, Amy Xu, Andrea Human, Annet van Royen‐Kerkhof, Arthur Cheng, Berent Prakken, Bianca Lang, Brenleigh Jebb, Brian Feldman, Bruno Pereira, Chelsea DeCoste, Ciarán Duffy, Claire LeBlanc, Clare Hutchinson, Daniah Basodan, Danielle Brinkman, David Cabral, Dax G. Rumsey, Deborah Levy, Dilan Dissanayake, Elizabeth Legger, Elizabeth Stringer, Elizaveta Limenis, Ellen Schatorje, Elodie Boudes, Erika Van Nieuwenhove, Erkan Demirkaya, Esther Hoppenreijs, Evelyn Rozenblyum, Gaëlle Chédeville, Gillian Currie, Giske Biesbroek, Gordon Soon, Harper Cheng, Heinrike Schmeling, Herman Tam, Hon Yan Ng, Jaime Guzman, Jeanine McColl, Jennifer Ji Young Lee, Jonathan Park, Joseph Cafazzo, Kate Neufeld, Kim Morishita, Kristin Houghton, Liane Heale, Lillian Lim, Lily Lim, Lori Tucker, Lynn Spiegel, Maarten IJzerman, Marc Jansen, Mariken Gruppen, Marinka Twilt, Marleen Verkaaik, Mehul Jariwala, Mercedes Chan, Michelle Batthish, Michelle Kip, Muhammed Dhalla, Nadia Luca, Nickolas Blanchette, Nico Wulffraat, Nicole Johnson, Paivi Miettunen, Paul Dancey, Petra Hissink Muller, Philomine van Pelt, Piya Lahiry, Ravneet Sran, Rayfel Schneider, Rebeka Stevenson, Regina de Geus, Roberta Berard, Roman Jurencak, Ronald Laxer, Rosie Scuccimarri, Ross Petty, Ruud Verstegen, Sarah Campillo, Shirley Tse, Suzanne Ramsey, Sylvia Kamphuis, Tala El Tal, Tania Cellucci, Tara McGrath, Tommy Gerschman, Trang Duong, Tristan Kerr, Wineke Armbrust   +102 more
wiley   +1 more source

Diagnostic implications and correlates of plasma ADA2 activity and ADA2 variants

Arthritis &Rheumatology, Accepted Article.
Objectives Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease manifested as polyarteritis nodosa, stroke, and bone marrow failure. Leveraging an international cohort of 200 DADA2 cases, we aimed to characterize the diagnostic utility of a plasma ADA2 enzyme activity assay and understand the implications of residual ADA2
Jian Yue, Courtney E. LeSon, Casey A. Rimland, Kailey Brodeur, Rachel Weng, Evan E. Hsu, Michael T. Lam, Manpreet Meyer, Seigo Okada, Andrew L. D. Hsu, Musaab A. Alhezam, Megan M. Perron, Olha Halyabar, Fatma Dedeoglu, Peter A. Nigrovic, Akiko Shimamura, R. Grant Rowe, Megan A. Cooper, Tiphanie P. Vogel, Miriah Gillispie‐Taylor, Rosemary Peterson, Clara Lin, Katherine D. Nowicki, Kaylee Dollerschell, Taizo A. Nakano, Roxane Labrosse, Alexis‐Virgil Cochino, Andreea Ioan, Leonardo Oliveira Mendonca, Samar Freschi Barros, Jorge Kalil, Javier Perez Rojas, Alicia Diaz Kuan, Eric S. Sobel, Taha Moussa, Samuel Shang Ming Lee, Li Wearn Koh, Archana Khan, Sodality Sutnga, Raju Khubchandani, Walaa Shoman, Yasmine El Chazli, Benzeeta Pinto, Chengappa Kavadichanda, Roshini S. Abraham, Xiangwei Sun, Qing Zhou, GSRSNK Naidu, Aman Sharma, Carl Esperanzate, Daniel L. Kastner, Ivona Aksentijevich, Susan J. Kelly, Michael Hershfield, Teresa K. Tarrant, Pui Y. Lee   +55 more
wiley   +1 more source

Semaglutide Exacerbates Stunting in Growth-Impaired Juvenile Male Mice via Reduced Energy Metabolism. [PDF]

J Endocr Soc
Joly A, Rebiffé L, Dusabyinema Y, Dellinger J, Caillon E, Gauthier K, Leulier F, De Vadder F.   +7 more
europepmc   +1 more source

The efficacy of Telitacicept in Childhood‐onset Systemic Lupus Erythematosus: a prospective multi‐center cohort study with IPTW‐adjusted comparison to a historical control group treated with Belimumab

Arthritis &Rheumatology, Accepted Article.
Objective The therapeutic effects of Telitacicept combined with standard of care (SoC) in childhood‐onset systemic lupus erythematosus (cSLE) remain unclear. This study aims to evaluate its efficacy in comparison with Belimumab combined with SoC. Methods We performed a prospective cohort study across 7 tertiary hospitals in China, enrolling patients ...
Chong Luo, Shu Su, Jingyue Liu, Junyu Lin, Jin Song, Zongwen Chen, Yuanyuan Peng, Lijun Jiang, Meng Jia, Li Wang, Xinhui Jiang, Wei Zhang, Zanhua Rong, Bo zhao, Yajun Wang, Xuemei Tang   +15 more
wiley   +1 more source

Intermittent Glucocorticoid Pulse Combined With Mycophenolate Mofetil in Juvenile Dermatomyositis.

JAMA Dermatol
Guo L, Liu J, Xin M, Yu G, Zhu C, Zhao X, Yang S.   +6 more
europepmc   +1 more source

The effects of pyridine hydrochloride on sublethal behavioural endpoints in the common shore crab, Carcinus maenas. [PDF]

Ecotoxicology
Giraud EAJ, Ford AT.
europepmc   +1 more source