Results 41 to 50 of about 393,493 (318)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Some peculiarities of organising the interrogation of a juvenile (minor) victim under martial law

Bulletin of Kharkiv National University of Internal Affairs, 2023
Based on the analysis of the Code of Criminal Procedure and the scientific work of scholars and practitioners, it has been established that criminal justice for juveniles (minors) should be structurally separated from adult justice, carried out in ...
M. V. Kryvonos
doaj   +1 more source

Metabolic and Microvascular Risk Factors Associated With Brain Health in Type 1 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We examined relationships between metabolic factors, microvascular complications, and brain health in adults with type 1 diabetes. Fifty‐one adults were assessed for metabolic risk factors, microvascular complications, and cognitive function, with a subset completing brain MRI.
Jihyun Park, Emily J. Koubek, Richard Beare, Lynn Ang, Brian C. Callaghan, Rodica Pop‐Busui, Eva L. Feldman, Evan L. Reynolds   +7 more
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Association between the Big Five personality traits and suicide‐related behaviors in Japanese institutionalized youths

PCN Reports
Aim Inmates in correctional institutions experience higher rates of suicide attempt (SA), suicidal ideation (SI), and nonsuicidal self‐injury (NSSI) than the general population. This study aimed to examine the association between the Big Five personality
Masaru Takahashi, Kasumi Imahara, Yukiko Miyamoto, Kayoko Myojo, Michiko Yasuda   +4 more
doaj   +1 more source

A space-gamified approach to examine muscle contraction behaviour in children and adolescents with spastic cerebral palsy: feasibility, acceptability and repeatbility

Frontiers in Pediatrics
IntroductionCerebral palsy (CP) is the most common disease affecting mobility among children. However, relatively little is known about the muscle phenotype and the resulting impairments in muscle function of this population.
Jule Heieis, Jule Heieis, Jule Heieis, Ibrahim Duran, Ibrahim Duran, Eckhard Schönau, Eckhard Schönau, Christoph Fritzsche, Bettina Götz, Laura Kehe, Moritz Meier, Karoline Spiess, Wilhelm Bloch, Jörn Rittweger, Jörn Rittweger   +14 more
doaj   +1 more source

Alterations of Amino Acids and Monoamine Metabolism in Male Fmr1 Knockout Mice: A Putative Animal Model of the Human Fragile X Mental Retardation Syndrome

Neural Plasticity, 2001
The Fragile X syndrome, a common form of mental retardation in humans, is caused by silencing the fragile X mental retardation (FMR1) geneleading to the absence of the encoded fragile X mental retardation protein 1 (FMRP).
Michael Gruss, Katharina Braun
doaj   +1 more source

Juvenile spondyloarthritis [PDF]

Current Opinion in Rheumatology, 2015
This article provides a comprehensive update of the pathogenesis, diagnostic imaging, treatments, and disease activity measurements of juvenile spondyloarthritis (JSpA).Genetic and microbiome studies have provided new information regarding possible pathogenesis of JSpA.
Sabrina, Gmuca, Pamela F, Weiss
openaire   +2 more sources

Validation of the Pediatric Arthritis Ultrasound Scoring System for the Elbow, Wrist, and Finger Joints in Children With Juvenile Idiopathic Arthritis

Arthritis Care &Research, EarlyView.
Objective We aimed to validate the Pediatric Arthritis Ultrasound Scoring System (PAUSS) for upper extremity joints in children with juvenile idiopathic arthritis (JIA). Methods Children with JIA were evaluated for elbow, wrist, or finger arthritis by clinical examination (CE) and musculoskeletal ultrasound (MSUS) with images scored according to the ...
Patricia Vega‐Fernandez, Pinar Ozge Avar‐Aydin, Kelly Rogers, Daniel J. Lovell, Jennifer Huggins, Alexei Grom, Hermine I. Brunner, Grant S. Schulert, Sheila T. Angeles‐Han, Mekibib Altaye, Amy Cassedy, Arthur B. Meyers, Tracy V. Ting   +12 more
wiley   +1 more source

Dyrektywy wymierzania kary dla młodocianego skazanego za zabójstwo kwalifikowane – glosa do postanowienia Sądu Najwyższego z dnia 26 lutego 2020 r., V KK 382/19

Problemy Prawa Karnego, 2021
In the presented gloss, the author, on the basis of the decision of the Supreme Court, analyzes the relation of Article 54 § 1 to Articles 53 § 1 and 3 of the criminal code.
Olga Sitarz
doaj   +1 more source