Results 11 to 20 of about 303,312 (346)

Type 1 interferonopathy presenting as juvenile idiopathic arthritis with interstitial lung disease: report of a new phenotype

Pediatric Rheumatology Online Journal, 2020
Background STING-associated vasculopathy with onset in infancy (SAVI) is a type 1 interferonopathy manifesting as a pulmonary and vascular syndrome resulting from gain-of-function mutations in TMEM173, the gene encoding STING.
S. L. N. Clarke, L. Robertson, G. I. Rice, L. Seabra, T. N. Hilliard, Y. J. Crow, A. V. Ramanan   +6 more
doaj   +2 more sources

What Is Rheumatoid Arthritis?

Journal of the American Medical Association (JAMA), 2022
ABRIDGED PRESCRIBING INFORMATION : ExemptiaTM (Adalimumab) 40 mg /0.8 mL single use pre filled syringe INDICATIONS AND USAGE Moderate to severe Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA): Moderate to severe active polyarticular JIA in
Melanie H Smith, J. Berman
semanticscholar   +1 more source

IL-6 Revisited: From Rheumatoid Arthritis to CAR T Cell Therapy and COVID-19.

Annual Review of Immunology, 2022
The diverse biological activity of interleukin-6 (IL-6) contributes to the maintenance of homeostasis. Emergent infection or tissue injury induces rapid production of IL-6 and activates host defense through augmentation of acute-phase proteins and immune
T. Kishimoto, Sujin Kang
semanticscholar   +1 more source

Definition and Validation of the American College of Rheumatology 2021 Juvenile Arthritis Disease Activity Score Cutoffs for Disease Activity States in Juvenile Idiopathic Arthritis

Arthritis & Rheumatology, 2021
To develop and validate new Juvenile Arthritis Disease Activity Score 10 (JADAS10) and clinical JADAS10 (cJADAS10) cutoffs to separate the states of inactive disease (ID), minimal disease activity (MiDA), moderate disease activity (MoDA), and high ...
C. Trincianti, E. H. P. van Dijkhuizen, A. Alongi, M. Mazzoni, J. Swart, I. Nikishina, P. Lahdenne, L. Rutkowska-Sak, T. Avčin, P. Quartier, V. Panavienė, Y. Uziel, C. Pruunsild, V. Vargova, S. Vilaiyuk, P. Doležalová, S. Ringold, M. Garrone, N. Ruperto, A. Ravelli, A. Consolaro   +20 more
semanticscholar   +1 more source

Factors Associated With Preterm Delivery Among Women With Rheumatoid Arthritis and Women With Juvenile Idiopathic Arthritis

Arthritis care & research, 2019
Pregnant women with inflammatory arthritis may be at increased risk for preterm delivery (PTD), yet it is unclear what drives this risk. This aim of this prospective cohort study of pregnant women with rheumatoid arthritis (RA), juvenile idiopathic ...
Chelsey J. F. Smith, F. Förger, G. Bandoli, C. Chambers   +3 more
semanticscholar   +1 more source

Systemic-onset juvenile idiopathic arthritis

Definitions, 2020
NATURE REVIEWS | DRUG DISCOVERY www.nature.com/reviews/drugdisc Supplementary table S1 | Broad Spectrum of Diseases Responsive to Anakinra Disease Condition References Joint, Bone and Muscle Diseases rheumatoid arthritis 1-21 psoriatic arthritis 22,23 ...

semanticscholar   +1 more source

Brief Report: The Genetic Profile of Rheumatoid Factor–Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis

Arthritis & Rheumatology, 2018
Juvenile idiopathic arthritis (JIA) comprises 7 heterogeneous categories of chronic childhood arthritides. Approximately 5% of children with JIA have rheumatoid factor (RF)–positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA)
A. Hinks, M. Marion, J. Cobb, M. Comeau, M. Sudman, H. Ainsworth, J. Bowes, M. Becker, J. Bohnsack, J. Haas, D. Lovell, E. Mellins, J. Lee Nelson, E. Nordal, M. Punaro, Ann M. Reed, Carlos D. Rosé, Alan M. Rosenberg, M. Rygg, Samantha L. Smith, A. Stevens, V. Videm, C. Wallace, Lucy R. Wedderburn, A. Yarwood, R. Yeung, C. Langefeld, S. Thompson, W. Thomson, S. Prahalad   +29 more
semanticscholar   +1 more source

Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature [PDF]

, 2015
Macrophage activation syndrome (MAS) is a potentially fatal condition. It is a rare complication of several autoimmune disorders, including systemic lupus erythematosus (SLE) and systemic juvenile idiopathic arthritis (sJIA).
Didona, Dario, Feola, Aldo, Granata, Guido, Granata, Massimo, Stifano, Giuseppina   +4 more
core   +4 more sources

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
Barton, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS), Eyre, S., Flynn, E., Gardner-Medwin, J. [CAPS and BSPAR study groups], Hinks, A., Ke, X., Martin, P., Packham, J., Thomson, W., UKRAG Consortium, Worthington, J.   +12 more
core   +1 more source

Tocilizumab in the Treatment of Juvenile Rheumatoid Arthritis

Zdorovʹe Rebenka, 2015
In the development of rheumatic diseases, especially juvenile rheumatoid arthritis, the important role of some cytokines, most important of which are interleukin-1, interleukin-6 and tumor necrosis factor α, has been proved.
V.V. Berejniy, T.V. Marushko, O.B. German, Ye.Yu. Marushko   +3 more
doaj   +1 more source