Results 171 to 180 of about 313,990 (261)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

[Retracted] miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. [PDF]

Mol Med Rep
Bai YY, Niu JZ.
europepmc   +1 more source

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Parental Perspectives on the Use of Smartwatch Activity Trackers by Young Children: Qualitative Study. [PDF]

JMIR Pediatr Parent
Davey RJ, Campbell A, Beynon A, Rasmussen CL, Hendry D, Stearne S, Harris C, Straker L, Zabatiero J.   +8 more
europepmc   +1 more source

Directional Regulation of Zinc Deposition Through Constructing Hierarchical Janus Carbon Matrix with Organic‐Decorated Multi‐Channels

Advanced Science, EarlyView.
A Janus carbon matrix is engineered by covalently anchoring organic sulfonic anions within tubular pores of hierarchical CMK‐5, serving as an interfacial layer for Zn metal anodes. This design establishes a charge gradient for Zn2+ diffusion, enabling the directional deposition of confined and uniform Zn inside the pores while suppressing parasitic ...
Li Gao, Hongli Chen, Dongfang Li, Chen Qian, Chao Yuan, Bin Yu, Jitraporn Vongsvivut, Bernt Johannessen, Lingfei Zhao, Yaojie Lei, Hong Gao, Yufei Zhao, Jinqiang Zhang, Guoxiu Wang, Hao Liu   +14 more
wiley   +1 more source

Reprogrammable Phase‐Transition Composites for Adaptive Dynamic Shape Morphing

Advanced Science, EarlyView.
This paper reports a bio‐inspired reprogrammable phase‐transition composites that uses the stiffness change induced by reversible solid‐liquid phase transition to program and regulate the material deformation actuated by reversible liquid‐vapor phase transition, thereby achieving adaptive dynamic deformation in a controllable manner, and enabling ...
Yiding Zhong, Wei Tang, Xinyu Guo, Kecheng Qin, Pingan Zhu, Qincheng Sheng, Yonghao Wang, Huayong Yang, Jun Zou   +8 more
wiley   +1 more source

ERRα-KDM5C restrains STING enhancer activity to modulate type I interferon signaling in breast cancer progression. [PDF]

Cell Death Dis
Xu ZH, Chen J, He Y, Lei C, Wang XL, Huang DF, Li ZZ, Zhou H, Wang MY, Song CG, Lin J, Liu W, Wu XN, Zhang WJ.   +13 more
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Oral <i>Prevotella</i> induces fat taste impairment, visceral lipid accumulation and insulin resistance by downregulating Hedgehog signaling in taste buds. [PDF]

J Oral Microbiol
Liu X, Zhang J, He Y, Zhang Q, Du S, Zeng T, Zhang J, Zhang H, Luo H, Li H, Wang Y, Peng M, Zhang N, Chen Q, Huang H, Wang P, Chen L, Hu X.   +17 more
europepmc   +1 more source