Results 181 to 190 of about 316,097 (265)

A Protein‐Centric Strategy Coupled with Match‐Between‐Run Glycoproteomics Enables Discovery of Robust Site‐Specific Glycan Biomarkers for Hepatocellular Carcinoma

Advanced Science, EarlyView.
In this study, a highly robust N‐glycoproteomics (HRN) platform with a newly developed match‐between‐run scheme is used for biomarker discovery. This study proposes a protein‐centric strategy to prioritize proteins susceptible to aberrant glycosylation.
Lei Liu, Taiheng Ma, Qi Liu, He Zhu, Zheng Fang, Jiahong Ma, Ting Yu, Yan Wang, Jiahua Zhou, Xiaoyan Liu, Yaqian Li, Zhimou Guo, Xinmiao Liang, Mingming Dong, Deguang Sun, Mingliang Ye   +15 more
wiley   +1 more source

Efficacy of Acupuncture for Mild to Moderate Depression in Older People: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc
Fu Q, Xiao K, Zhang J, Li Y, Wang Y, Jiang M, Man Z, Yang J, Lu W.   +8 more
europepmc   +1 more source

Visualizing Strain‐Coupled Cryogenic Phase Transitions and Defect Dynamics in Perovskite Quantum Dots Using In Situ STEM

Advanced Science, EarlyView.
Cryogenic cooling induces an orthorhombic‐to‐monoclinic phase transition in CsPbBr3 quantum dots, accompanied by pronounced strain localization at surfaces and interfaces. Multimodal in situ STEM directly visualize reversible defect healing during moderate cryogenic treatment and irreversible degradation upon prolonged exposure, revealing the intrinsic
Xinjuan Li, Zhao Jiang, Si Chen, Yi Tang, Bofeng Xue, Tianhao Wu, Yang Lu, Xavier Moya, Akshay Rao, Zhongzheng Yu, Caterina Ducati   +10 more
wiley   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

DNA‐Guided Robust Single‐Protein Electronic Readout

Advanced Science, EarlyView.
Electronic measurements of single proteins can reveal fundamental insights into their structure, dynamics, and interactions, but reproducibility is severely limited by the intrinsic structural heterogeneity of proteins combined with uncontrolled molecular orientation and electrode contact geometries.
Ziyi Ju, Zhaoxiang Deng, Yueqi Li, Jinghong Li   +3 more
wiley   +1 more source

A catalog of Cassidinae leaf beetles (Coleoptera, Chrysomelidae) collection deposited in the Insect Collection of the College of Agriculture, Yangtze University, China. [PDF]

Zookeys
Yang C, Zhang L, Wang P, Xie G, Wang W.
europepmc   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Multi‐Soliton Microcombs Enable Ultrafast Nanometric‐Precision Ranging and Photon‐Level Detection

Advanced Science, EarlyView.
Our work first demonstrates dual‐multi‐soliton ranging and confirms its multifunctional capability. The method achieves ultrafast and nanometric‐precision measurement. For practical applications, we further extend the multi‐soliton states to photon‐level ranging.
Jiawen Zhi, Xiaoyang Guo, Xusheng Yang, Brent E. Little, Sai T. Chu, Chenggang Shao, Mengyu Wang, Yan Liang, Peng Xie, Weiqiang Wang, Hanzhong Wu   +10 more
wiley   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Correction: Spatial heterogeneity of microbial community structure and its environmental drivers in surface sediments of Erhai Lake. [PDF]

PLoS One
Xiang H, Yang CG, Xiong HQ, Bao HR, Qu JZ, Luan ZX, Sun XL, Li Z.   +7 more
europepmc   +1 more source