Results 121 to 130 of about 20,117,092 (282)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

World Languages in Online and Blended K-12 Education

open access: yes, 2018
This chapter is a qualitative exploration and synthesis of research on online world-language courses in K-12 settings, focusing on such courses’ e¢ectiveness and the unique challenges of maintaining the quality of language courses as they move from face ...
Lin, C, Zheng, B, Hsu, Y
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

K-State First Co-Curricular Guide 2019

open access: yes, 2019
Citation: K-State First (2019). K-State First Co-Curricular Guide 2019. Manhattan, Kansas: K-State First.Co-curricular events have a huge impact on student learning and community building. Students often note that they remember these out of the classroom
Kansas State University, K-State First
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

K-12 Education in the Age of AI: A Call to Action for K-12 AI Literacy

open access: yesInternational Journal of Artificial Intelligence in Education, 2023
Ning Wang, James C. Lester
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Bericht über das Schuljahr ... / K. K. Staats-Gewerbeschule Linz

open access: yes, 1912
BERICHT ÜBER DAS SCHULJAHR ... / K. K. STAATS-GEWERBESCHULE LINZ Bericht über das Schuljahr ... / K. K. Staats-Gewerbeschule Linz Bericht über das Schuljahr ... / K. K.

core   +1 more source

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