Results 121 to 130 of about 6,676 (283)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Pozitivno razumevanje svobode v Cankarjevih Hlapcih

Jezik in Slovstvo
Cankarjeva drama Hlapci je nastajala v času kulturnega boja in vsebuje – redko izpostavljene – politične teze, ki so vse od prve objave drame močno vplivale na oblikovanje slovenskega kolektivnega spomina. Hlapec kot ključna beseda slovenske kulture je v
Jasmina Šuler Galos
doaj   +1 more source

Analisis Konsumerisme Budaya Korea Selatan (K-Drama) Terhadap Mahasiswa Universitas Nusantara PGRI Kediri [PDF]

Penelitian ini membahas pengaruh konsumenisme budaya Korea Selatan (K-Drama) terhadap mahasiswa Universitas Nusantara PGRI Kediri. Para remaja di Indonesia mulai mengonsumsi budaya Korea Selatan dan sangat antusias terhadap maraknya Korean Wave di ...
Anugrah, Betha Widi, Damariswara, Rian, Diningrum, Marcella Eka Widya, Salsabila, Thalita Alya   +3 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

PERILAKU PENGGEMAR K-POP DAN K-DRAMA PADA SISWA SMA/MA DI KOTA MATARAM [PDF]

The purpose of this research is to understand the behavior of high school K-Pop and K-Drama fans in Mataram city and to examine the impact of K-Pop and K-Drama on these students' behavior.
Irmasuci, Dayu, Masyhuri, Masyhuri, Nursaptini, Nursaptini, Suryanti, Ni Made Novi   +3 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Конструирование идентичности Республики Корея в регионе Северо-Восточная Азия [PDF]

, 2016
Рассматриваются основные стадии развития процесса конструирования идентичности Республики Корея, которые связаны с внешнеполитическими ориентирами и степенью государственной поддержки, новейшие инструменты формирования образа Кореи за рубежом, которые ...
Задворная, Е. С.
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source