Results 241 to 250 of about 14,634,982 (301)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Genetic canalization of nutrient resorption in the widespread grass <i>Phragmites australis</i> under salt stress. [PDF]

Elife
Liu L, Sheng W, Song H, Wang C, Li N, Lin L, Guo Y, Du N, Guo W.   +8 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Spherical Metadensity Functional Learning for Inhomogeneous Classical Fluids. [PDF]

J Chem Theory Comput
Kampa SM, Schmidt M, Sammüller F.
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Effect of action observation training on upper functioning and self-care in individuals with mental illness: a randomized controlled pilot trial. [PDF]

J Phys Ther Sci
Kim JC, Song YH, Park GH.
europepmc   +1 more source

Editorial: Microbiome-driven strategies for alleviation of biotic and abiotic stresses in agriculture. [PDF]

Front Microbiol
Kumar S, Meena KK, Sorty AM, Wakchaure GC, Kumar M.   +4 more
europepmc   +1 more source

Comparative Conformational Sampling of Apo Adenylate Kinase by Enhanced Molecular Dynamics and a Sequence-Based Generative Ensemble Model. [PDF]

Molecules
Zhao Q, Cui T, Li Y.
europepmc   +1 more source

MRI-Derived Evaluation of Liver Function and Its Extension to K-Edge Photon-Counting CT: Focus on Gadolinium-Based Functional Biliary Imaging. [PDF]

Diagnostics (Basel)
Asmundo L, Vicentin I, Ghilardi G, Monti CB, Vanzulli A, Rizzetto F, Mariani L, Steffani S, Centonze L, Mazzarelli C, Albano D, Sandro SD, Vanzulli A.   +12 more
europepmc   +1 more source