Results 81 to 90 of about 1,835,018 (264)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Statistical Software, 2012 Clustering text documents is a fundamental task in modern data analysis, requiring approaches which perform well both in terms of solution quality and computational efficiency.
Kurt Hornik +3 more
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Ilkom Jurnal Ilmiah, 2019 University as an educational institution plays an important role in producing graduates. In addition, institutions such as universitas ichsan Gorontalo save the data set.
Suhardi Rustam, Haditsah Annur
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Federated learning is a technique that enables the use of distributed datasets for machine learning purposes without requiring data to be pooled, thereby better preserving privacy and ownership of the data. While supervised FL research has grown substantially over the last years, unsupervised FL methods remain scarce.
Swier Garst, Marcel J. T. Reinders
openaire +2 more sources
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Implementasi KD-Tree K-Means Clustering untuk Klasterisasi Dokumen
Jurnal Teknik ITS, 2013 Klasterisasi dokumen adalah suatu proses pengelompokan dokumen secara otomatis dan unsupervised. Klasterisasi dokumen merupakan permasalahan yang sering ditemui dalam berbagai bidang seperti text mining dan sistem temu kembali informasi.
Eric Budiman Gosno +2 more
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