Results 221 to 230 of about 1,838,529 (264)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

k -means: A revisit

open access: yesNeurocomputing, 2018
Abstract Due to its simplicity and versatility, k-means remains popular since it was proposed three decades ago. The performance of k-means has been enhanced from different perspectives over the years. Unfortunately, a good trade-off between quality and efficiency is hardly reached. In this paper, a novel k-means variant is presented.
Wan-Lei Zhao, Chong Wah Ngo
exaly   +4 more sources

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