Results 111 to 120 of about 14,276,290 (299)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Quantum k-Means Clustering Using Hadamard-Test-Based Similarity Estimation
ComputersRecently, the volume of the generated data has increased significantly, leading to the need for computational techniques capable of handling such data efficiently.
Mohammadhadi Alaeiyan +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
RACK: RApid Clustering using K-means algorithm
, 2009 The k-means algorithm is an extremely popular technique for clustering data. One of the major limitations of the k-means is that the time to cluster a given dataset D is linear in the number of clusters, k.
Murty, MN, Garg, Vikas K
core
Analisis Karakteristik Mahasiswa Berdasarkan Nilai Kelompok Mata Kuliah dengan Menggunakan Analisis Cluster K-Means [PDF]
, 2019 Indeks Prestasi (IP) adalah nilai yang dihitung berdasarkan jumlah beban studi yang diambil dalam satu semester dikalikan dengan bobot prestasi tiap-tiap mata kuliah kemudian dibagi dengan jumlah beban kredit yang diambil. IPK merupakan IP kumulatif dari
Yahdin, Sugandi +2 more
core +1 more source
Ilkom Jurnal Ilmiah, 2019 University as an educational institution plays an important role in producing graduates. In addition, institutions such as universitas ichsan Gorontalo save the data set.
Suhardi Rustam, Haditsah Annur
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2016 Map of the distribution of materials and their classification according to the k-means method.
Alfonso Benito-Calvo (559798) +3 more
core +1 more source