Results 181 to 190 of about 13,094,494 (259)
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Breathing K-Means: Superior K-Means Solutions through Dynamic K-Values [PDF]
We introduce the breathing k-means algorithm, which on average significantly improves solutions obtained by the widely-known greedy k-means++ algorithm, the default method for k-means clustering in the scikit-learn package.
Fritzke, Bernd
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
K-means and adaptive k-means algorithms for clustering DNS traffic [PDF]
Proceedings of the 5th International ICST Conference on Performance Evaluation Methodologies and Tools, 2011 Qinghui Xu +3 more
openaire +1 more source
Improved K-means algorithm for manufacturing process anomaly detection and recognition
, 2006 Anomaly detection and recognition are of prime importance in process industries. Faults are usually rare, and, therefore, predicting them is difficult .
Shi HB(史海波) +2 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
ANALISIS K-MEANS CLUSTER INDEKS PEMBANGUNAN MANUSIA DI INDONESIA
, 2019 Pembangunan manusia dalam suatu negara diperlukan untuk menciptakan kesejahteraan dan membuat perkembangan dalam suatu negara sehingga perlu dilihat terlebih dahulu kualitas sumber daya manusia dalam negara tersebut.
ANALISIS K-MEANS CLUSTER INDEKS PEMBANGUNAN MANUSIA DI INDONESIA, 4112315018
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