Results 101 to 110 of about 10,955,529 (276)

Synthesis of Oligo‐Sulfonimidates by Exponential Growth via Sulfur‐Phenolate Exchange Reactions

ChemistryEurope, EarlyView.
A highly flexible iterative exponential growth strategy is used in combination with the sulfur‐phenolate exchange reaction to develop sequence‐defined oligosulfonimidates (16 mer). Combining this with sulfur‐fluorine exchange‐based iterative step growth, a bespoke 20 mer (Mw = 8.5 kDa) can be synthesized.
Yu Han, Dong‐Dong Liang, Silke Heskamp, Bo Chen, Fedor M. Miloserdov, Han Zuilhof   +5 more
wiley   +1 more source

Optimization of de novo transcriptome assembly from high-throughput short read sequencing data improves functional annotation for non-model organisms

BMC Bioinformatics, 2012
Background The k-mer hash length is a key factor affecting the output of de novo transcriptome assembly packages using de Bruijn graph algorithms. Assemblies constructed with varying single k-mer choices might result in the loss of unique contiguous ...
Haznedaroglu Berat Z, Reeves Darryl, Rismani-Yazdi Hamid, Peccia Jordan   +3 more
doaj   +1 more source

Mini‐Hairpin DNA: Extraordinarily Stable Structure and Its Applications

Chemistry – A European Journal, EarlyView.
Mini‐hairpin DNA fragments containing GCGAAGC and GCGAAAGC form exceptionally stable hairpin‐like structures, with only two G−C pairs and one sheared G−A pair, remaining undenatured in 7 M urea and resisting nuclease digestion. These mini‐hairpin sequences frequently appear in replication and transcription origins, influence DNA sequencing fidelity ...
Michiko Kimoto, Ichiro Hirao
wiley   +1 more source

An alignment-free method for detection of missing regions for phylogenetic analysis

Heliyon
Phylogenetic tree estimation using conventional approaches usually requires pairwise or multiple sequence alignment. However, sequence alignment has difficulties related to scalability and accuracy in case of long sequences such as whole genomes, low ...
Rubyeat Islam, Atif Rahman
doaj   +1 more source

K-mers in metagenomics

, 2015
­ K ­-mers play a critical role in the exploration of metagenomic data. They have been widely used to assign taxonomic attributions to the short genomic fragments characteristic of shotgun (metagenomic) sequencing. These approaches provide an assembly-free method for profiling microbial communities,
openaire   +1 more source

The evolutionary landscape and serotypic dynamics of avian infectious bronchitis virus from spike protein

iMetaOmics, EarlyView.
This study integrates two decades of surveillance with genomic and structural analyses to decipher how spike protein glycosylation haplotypes drive avian coronavirus evolution. We uncover how specific glycosylation patterns associate with receptor‐binding affinity, shape global transmission dynamics, and correlate with clinical outcomes.
Hao Zhang, Zongxi Han, Chuangchao Zou, Yihui Huang, Shiping Sun, Ouyang Peng, Usama Ashraf, Qiuping Xu, Yao Ge, Qixiang Kang, Xiuli Ma, Xinheng Zhang, Ye Zhao, Xin Yang, Hongning Wang, Guozhong Zhang, Qingmei Xie, Mang Shi, Yongsen Ruan, Min Liao, Shengwang Liu, Yongchang Cao   +21 more
wiley   +1 more source

Configurational entropy for adsorbed linear species (k-mers)

The Journal of Chemical Physics, 2001
The configurational entropy of interacting linear molecules (k-mers) absorbed on a regular lattice is addressed through analytical as well as numerical methods. The general definitions for computational exact calculations of k-mers lattice-gas entropy are presented.
F. Romá, A. J. Ramírez-Pastor, J. L. Riccardo   +2 more
openaire   +2 more sources

Fast bootstrap and reliable readout using hidden references for DNA data storage

iMeta, EarlyView.
This study provides a bootstrap readout framework for DNA data storage based on multiple‐fold hidden references. We employ a multi‐stage alignment and error correction strategy, transforming the de novo readout into a resequencing‐like workflow. Correlation to the hidden watermark reference identifies low‐error‐rate reads, and bit‐wise consensus ...
Weigang Chen, Shuang Liu, Quan Guo, Rui Qin, Qi Ge, Tingting Qi, Yingjin Yuan   +6 more
wiley   +1 more source

Direct Detection of Viruses Using Antibody‐Modified Gold Nanorods

Journal of Biophotonics, EarlyView.
Gold nanorods functionalized with pathogen‐specific antibodies can be used for the confirmatory detection of viruses via dynamic light scattering–based analysis of particle sizes. ABSTRACT Seasonal and sporadic viral infections put enormous burdens on global health and society. Although polymerase chain reaction (PCR) and other molecular approaches can
Axell Rodriguez, Yana Purvinsh, Aidan P. Holman, Dmitry Kurouski   +3 more
wiley   +1 more source

MegaGTA: a sensitive and accurate metagenomic gene-targeted assembler using iterative de Bruijn graphs

BMC Bioinformatics, 2017
Background The recent release of the gene-targeted metagenomics assembler Xander has demonstrated that using the trained Hidden Markov Model (HMM) to guide the traversal of de Bruijn graph gives obvious advantage over other assembly methods. Xander, as a
Dinghua Li, Yukun Huang, Chi-Ming Leung, Ruibang Luo, Hing-Fung Ting, Tak-Wah Lam   +5 more
doaj   +1 more source