Results 131 to 140 of about 57,228 (156)
Acta Crystallographica Section D, Volume 81, Issue 6, Page 310-326, June 2025.The myricetin‐bound crystal structure of the SARS‐CoV‐2 helicase reveals a conserved allosteric binding site. Guided by these structural insights, caffeic acid derivatives identified through virtual screening were experimentally validated as novel natural inhibitors of NSP13.The SARS‐CoV‐2 helicase NSP13 is a highly conserved and essential component of
Patrick Kloskowski +5 more
wiley +1 more source
Sufficient reproduction numbers to prevent recurrent epidemics
Methods in Ecology and Evolution, Volume 16, Issue 6, Page 1186-1200, June 2025.Abstract Current practice in the design and evaluation of control measures in disease ecology and epidemiology, including vaccination, is largely based on reproduction numbers (RNs), which represent prognostic indices of long‐term disease transmission, both in naïve populations (basic RN) and in the presence of prior exposure or infection containment ...
Lorenzo Mari +3 more
wiley +1 more source
Revealing Kinetic Features of a Macrocyclization Reaction Using Machine‐Learning‐Augmented Data
Angewandte Chemie, Volume 137, Issue 21, May 19, 2025.A phrase closely associated with machine learning simulations, “to predict is not to explain”, can be rephrased as “to predict can be to explain” by integrating physicochemical, least‐squares fitting studies of kinetics with machine learning predictions.
Hiroyuki Isobe +3 more
wiley +2 more sources
MetaCon: unsupervised clustering of metagenomic contigs with probabilistic k-mers statistics and coverage. [PDF]
BMC Bioinformatics, 2019 Qian J, Comin M.
europepmc +1 more source
Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition
The FEBS Journal, Volume 292, Issue 11, Page 2865-2881, June 2025.The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda +5 more
wiley +1 more source
A classification model for lncRNA and mRNA based on k-mers and a convolutional neural network. [PDF]
BMC Bioinformatics, 2019 Wen J +5 more
europepmc +1 more source
Journal of Advanced Nursing, Volume 81, Issue 6, Page 3226-3239, June 2025.ABSTRACT Aim Describe the stressors that long‐term care facility (LTCF) residents and their family members were exposed to during the COVID‐19 pandemic, the resources they mobilised to cope with them, and the strategies used by professionals to support them. Design A descriptive qualitative design study.
Christine Cohen +3 more
wiley +1 more source
Journal of Evidence-Based Medicine, Volume 18, Issue 2, June 2025.ABSTRACT Aim High‐impact infectious diseases pose major global health challenges, underscoring the urgent need for robust public health preparedness. Despite efforts to improve global health security, recent pandemics have revealed significant weaknesses in health systems’ preparedness and response capabilities.
KM Saif‐Ur‐Rahman +9 more
wiley +1 more source
Estimating the total genome length of a metagenomic sample using k-mers. [PDF]
BMC Genomics, 2019 Hua K, Zhang X.
europepmc +1 more source
Bat‐Borne RNA Viruses: Addressing the Rising Health Risks in Bangladesh
Public Health Challenges, Volume 4, Issue 2, June 2025.
Md Nasir Ahmed
wiley +1 more source