Results 71 to 80 of about 10,955,529 (276)
LROD: An Overlap Detection Algorithm for Long Reads Based on k-mer Distribution
Frontiers in Genetics, 2020 Third-generation sequencing technologies can produce large numbers of long reads, which have been widely used in many fields. When using long reads for genome assembly, overlap detection between any pair of long reads is an important step.
Junwei Luo +6 more
doaj +1 more source
SKESA: strategic k-mer extension for scrupulous assemblies [PDF]
Genome Biology, 2018 SKESA is a DeBruijn graph-based de-novo assembler designed for assembling reads of microbial genomes sequenced using Illumina. Comparison with SPAdes and MegaHit shows that SKESA produces assemblies that have high sequence quality and contiguity, handles low-level contamination in reads, is fast, and produces an identical assembly for the same input ...
Alexandre Souvorov +2 more
openaire +3 more sources
Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents
Advanced Functional Materials, EarlyView.Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras +6 more
wiley +1 more source
Deep learning model for metagenome fragment classification using spaced k-mers feature extraction
Jurnal Teknologi dan Sistem Komputer, 2020 An open challenge in bioinformatics is the analysis of the sequenced metagenomes from the various environments. Several studies demonstrated bacteria classification at the genus level using k-mers as feature extraction where the highest value of k gives ...
Nur Choiriyati +2 more
doaj +1 more source
Superspreading and heterogeneity in transmission of SARS, MERS, and COVID-19: A systematic review
Computational and Structural Biotechnology Journal, 2021 Background: Severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and coronavirus disease 2019 (COVID-19) have caused substantial public health burdens and global health threats. Understanding the superspreading potentials of
Jingxuan Wang +10 more
doaj +1 more source
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, EarlyView.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Fast Approximation of Frequent k-Mers and Applications to Metagenomics [PDF]
Annual International Conference on Research in Computational Molecular Biology, 2019 Estimating the abundances of all k-mers in a set of biological sequences is a fundamental and challenging problem with many applications in biological analysis.
Leonardo Pellegrina +2 more
semanticscholar +1 more source
KAnalyze: a fast versatile pipelined K-mer toolkit [PDF]
Bioinformatics, 2014 Abstract Motivation : Converting nucleotide sequences into short overlapping fragments of uniform length, k-mers, is a common step in many bioinformatics applications. While existing software packages count k-mers, few are optimized for speed, offer an application programming interface (API), a graphical interface or contain features ...
Audano, Peter, Vannberg, Fredrik
openaire +2 more sources
Whole-Genome k-mer Topic Modeling Associates Bacterial Families [PDF]
Genes, 2020 Alignment-free k-mer-based algorithms in whole genome sequence comparisons remain an ongoing challenge. Here, we explore the possibility to use Topic Modeling for organism whole-genome comparisons. We analyzed 30 complete genomes from three bacterial families by topic modeling.
Ernesto Borrayo +5 more
openaire +2 more sources
Advanced Science, EarlyView.This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun +12 more
wiley +1 more source