Results 91 to 100 of about 10,402,191 (234)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

A Comparison of Petri Net Semantics under the Collective Token Philosophy

open access: yes, 1998
In recent years, several semantics for place/transition Petri nets have been proposed that adopt the collective token philosophy. We investigate distinctions and similarities between three such models, namely configuration structures, concurrent ...
Meseguer, J.   +7 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Játékfejlesztés .NET környezetben

open access: yes, 2017
A monopoly játék megvalósítása .NET környezetben. a megvalósítás C# nyelven készült és a hozzá tartozó grafikus felület a WPF technológiákra épül. A téma a megvalósításra alapul. A megvalósítás tartalmaz helyi és hálózati játékot.
Némethy, Attila Péter
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

MMPhU-Net: A Novel Multi-Model Fusion Phase Unwrapping Network for Large-Gradient Subsidence Deformation

open access: yesIEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The problem of phase unwrapping (PhU) in the large-gradient deformation areas is the bottleneck problem of interferometric synthetic aperture radar (InSAR) data processing.
Yandong Gao   +5 more
doaj   +1 more source

Laboratory and semi-field evaluation of long-lasting insecticidal nets against leishmaniasis vector, Phlebotomus (Phlebotomus) duboscqi in Kenya [PDF]

open access: yesJournal of Vector Borne Diseases, 2010
Background & objectives: Phlebotomine sandflies are vectors of leishmaniases and other diseases.Long-lasting insecticidal nets (LLINs) as possible tools for control have not been widely testedagainst them. The objective of this study was to determine the
Sichangi Kasili, Helen Kutima, Charles Mwandawiro, Philip M. Ngumbi , Christopher O. Anjili
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Effect of fertigation with potassium and nitrogen on gas exchange and biomass accumulation in eggplant

open access: yesPesquisa Agropecuária Tropical, 2017
Adequate crop fertilization is one of the challenges for agriculture. Measuring gas exchange and biomass accumulation may be used to adjust crop management. The effect of fertigation with potassium (0 kg ha-1, 54 kg ha-1, 108 kg ha-1 and 216 kg ha-1) and
Álvaro Henrique Cândido de Souza   +4 more
doaj  

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