Results 121 to 130 of about 2,629,717 (284)
Assessing the disclosure protection provided by misclassification for survey microdata
, 2009 Government statistical agencies often apply statistical disclosure limitation techniques to survey microdata to protect confidentiality. There is a need for ways to assess the protection provided.
Shlomo, Natalie, Skinner, Chris
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Lower k -record values from unit-Gompertz distribution and associated inference
Journal of Statistical Computation and SimulationMazucheli et al. (2019) introduced the unit-Gompertz (UG) distribution and studied some of its properties. More specifically, they considered the random variable X =exp(-Y), where Y has the Gompertz distribution. In this paper, we consider the lower k-record values from this distribution.
Ehsan Ormoz +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Nature CommunicationsHigh-temperature superconducting wires have many large-scale, niche applications such as commercial nuclear fusion as well as numerous other large-scale applications in the electric power industry and in the defense, medical and transportation industries.
A. Goyal +5 more
doaj +1 more source
Antimicrobial Stewardship & Healthcare EpidemiologyIntroduction: Infection by Extended Spectrum Beta-Lactamase (ESBL)-producing bacteria in Intensive Care Unit (ICU) is associated with treatment failure, prolonged hospital stay, increased costs and patient mortality.
Kian Sinanjung +3 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Inference for the Kumaraswamy distribution under
Journal of Computational and Applied Mathematics, 2017 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source