Results 101 to 110 of about 512,862 (249)

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

Molecular Oncology, EarlyView.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores, Diego M. Fernández‐Aroca, Cristina Garnés‐García, Andrés Domínguez‐Calvo, Jaime Jiménez‐Suárez, Sebastià Sabater, Pablo Fernández‐Aroca, Ignacio Andrés, Francisco J. Cimas, Guillermo de Cárcer, Borja Belandia, Ignacio Palmero, Pablo Huertas, María José Ruiz‐Hidalgo, Ricardo Sánchez‐Prieto   +14 more
wiley   +1 more source

The PTTG1/VASP axis promotes oral squamous cell carcinoma metastasis by modulating focal adhesion and actin filaments

Molecular Oncology, EarlyView.
VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park, Sang Shin Lee, Shihyun Kim, Yeonjun Lee, Gyeonwon Park, Jung Oh Kim, Jongho Choi   +6 more
wiley   +1 more source

An infrared-submillimeter study of star-forming regions selected by the ISOSS 170um survey

, 2008
Using the ISOPHOT Serendipity Survey (ISOSS) at 170um a sample of galactic star-forming regions exhibiting very cold dust temperatures (< 20 K) and high masses (> 100 M_sun) has been established.
Beuther, Beuther, Birkmann, Birkmann, Bogun, Brand, D. Lemke, Draine, Engelbracht, Evans, Fazio, Gordon, Holland, Indebetouw, Indebetouw, Kessler, Krause, Krause, Lemke, Low, M. Hennemann, Makovoz, McKee, Motte, O. Krause, Ossenkopf, Rathborne, Rathborne, Rawlings, Reach, Reach, Rieke, Robitaille, Robitaille, S. M. Birkmann, Sandell, Sault, Shepherd, Sridharan, Sridharan, Stickel, Werner, Whitney, Zinnecker   +43 more
core   +1 more source

SKA1 promotes oncogenic properties in oral dysplasia and oral squamous cell carcinoma, and augments resistance to radiotherapy

Molecular Oncology, EarlyView.
The mitosis‐related gene SKA1 was among 629 genes consistently dysregulated in OSCC across nine public gene expression datasets. In OSCC cell lines, SKA1 promoted proliferation and migration, enhanced radioresistance, and reduced radiation‐induced senescence.
Alexander Michael Grandits, Barbara Andrea Reinoehl, Renate Wagner, Peter Kuess, Franziska Eckert, Anna Sophie Berghoff, Thorsten Fuereder, Rotraud Wieser   +7 more
wiley   +1 more source

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

A young and complex binary star - HD 144432

, 2003
The southern emission-line star HD 144432 has received considerable attention due to its relative brightness (V ~ 8.17), its late spectral type (late A-type or perhaps early F) and its relative isolation from a bona-fide active star formation region.
B. W. Bopp, Blondel, Carballo, Catala, Corporon, D. de Winter, de Winter, Doppmann, Dunkin, Grady, Grady, Graham, Hamann, Hartmann, Hauck, Herbig, Hillenbrand, Jaschek, Jaschek, M. E. van den Ancker, M. R. Pérez, Maheswar, Meeus, Meeus, Merín, Oudmaijer, Palla, Pottasch, Pérez, Pérez, Rayner, Rossiter, Soderblom, Suchkov, Sylvester, Thé, Valenti, van Boekel, van den Ancker, van den Ancker, Wackerling, Walker, Walker, Welty, Zuckerman   +44 more
core   +1 more source

Impact of molecular diagnostics and targeted cancer therapy on patient outcomes (MODIFY): a retrospective study of the implementation of precision oncology

Molecular Oncology, EarlyView.
The authors conducted a retrospective study of 94 patients with advanced cancer who underwent next‐generation sequencing (NGS) gene panel analysis and received targeted treatments when applicable. Results further support evidence indicating that molecular profiling provides clinical benefit.
Michaël Dang, Anna Schritz, Nikolai Goncharenko, Guy Berchem   +3 more
wiley   +1 more source

Detection rate for ESR1 mutations is higher in circulating‐tumor‐cell‐derived genomic DNA than in paired plasma cell‐free DNA samples as revealed by ddPCR

Molecular Oncology, EarlyView.
Analysis of ESR1 mutations in plasma cell‐free DNA (cfDNA) is highly important for the selection of treatment in patients with breast cancer. Using multiplex‐ddPCR and identical blood draws, we investigated whether circulating tumor cells (CTCs) and cfDNA provide similar or complementary information for ESR1 mutations.
Stavroula Smilkou, Aliki Ntzifa, Victoria Tserpeli, Ioanna Balgkouranidou, Alkistis Papatheodoridi, Evangelia Razis, Helena Linardou, Christos Papadimitriou, Amanda Psyrri, Flora Zagouri, Stylianos Kakolyris, Evi Lianidou   +11 more
wiley   +1 more source

Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis

Molecular Oncology, EarlyView.
Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch, Sara Sánchez‐Serra, Marta Rosàs‐Lapeña, Nicolás Costa‐Fraga, Judit Besalú‐Velázquez, Janet Illa‐Bernadí, Silvia Mateo‐Lozano, Florencia Cidre‐Aranaz, Thomas G.P. Grünewald, Ángel Díaz‐Lagares, Roser Lopez‐Alemany, Òscar M. Tirado   +11 more
wiley   +1 more source

Testing Model Atmospheres for Young Very Low Mass Stars and Brown Dwarfs in the Infrared: Evidence for Significantly Underestimated Dust Opacities

, 2015
We test state-of-the-art model atmospheres for young very low-mass stars and brown dwarfs in the infrared, by comparing the predicted synthetic photometry over 1.2-24 {\mu}m to the observed photometry of M-type spectral templates in star-forming regions.
Mohanty, Subhanjoy, Tottle, Jonathan
core   +1 more source