Results 161 to 170 of about 536,015 (293)

Eclipsing binaries in open clusters. III. V621 Per in chi Persei

, 2004
V621 Persei is a detached eclipsing binary in the open cluster chi Persei which is composed of an early B-type giant star and a main sequence secondary component.
Andersen, Andersen, Argelander, B. Smalley, Bessell, Bidelman, Bressan, Capilla, Chen, Claret, Claret, Claret, Claret, Clausen, Crawford, Dufton, Dufton, Hron, J. Southworth, Keller, Kilian, Krzesiński, Kunzli, Kurucz, Lennon, Liu, Liu, Maeder, Marco, Marsh, Mermilliod, Moon, Moro, Nelson, Oosterhoff, P. F. L. Maxted, Pols, Popper, Rufener, S. Zucker, Schaller, Schröder, Simon, Slesnick, Smalley, Smith, Southworth, Southworth, Torres, Uribe, Van Hamme, Venn, Vrancken, Waelkens, Zucker   +54 more
core   +2 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

On internal wave breaking and tidal dissipation near the centre of a solar-type star

, 2010
We study the fate of internal gravity waves, which are excited by tidal forcing by a short-period planet at the interface of convection and radiation zones, approaching the centre of a solar-type star. We study at what amplitude these wave are subject to
Adrian J. Barker, Appourchaux, Barker, Booker, Breeding, Bühler, Christensen-Dalsgaard, Christensen-Dalsgaard, Christensen-Dalsgaard, Cowling, Drazin, Fritts, Garcia Lopez, García, Gillon, Goldreich, Goldreich, Goodman, Goodman, Goodman, Gordon I. Ogilvie, Gough, Hasselmann, Hazel, Hebb, Hebb, Hellier, Ivanov, Klostermeyer, Klostermeyer, Koop, Koop, Kumar, Lesur, Lesur, Maslowe, McIntyre, Ogilvie, Ogilvie, Ogilvie, Papaloizou, Papaloizou, Papaloizou, Peale, Penev, Press, Rogers, Sasselov, Savonije, Savonije, Savonije, Savonije, Schatzman, Staquet, Stone, Terquem, Winters, Witte, Witte, Witte, Wu, Zahn, Zahn, Zahn, Zahn, Zahn   +65 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Signatures of unresolved binaries in stellar spectra: implications for spectral fitting

, 2017
The observable spectrum of an unresolved binary star system is a superposition of two single-star spectra. Even without a detectable velocity offset between the two stellar components, the combined spectrum of a binary system is in general different from
Bergemann, Maria, Cargile, Phillip, Conroy, Charlie, Eilers, Anna-Christina, El-Badry, Kareem, Rix, Hans-Walter, Ting, Yuan-Sen, Weisz, Daniel R.   +7 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source