Results 31 to 40 of about 42,939 (197)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Searching for GEMS: Characterizing Six Giant Planets Around Cool Dwarfs

The Astronomical Journal
Transiting giant exoplanets around M-dwarf stars (GEMS) are rare, owing to the low-mass host stars. However, the all-sky coverage of TESS has enabled the detection of an increasingly large number of them to enable statistical surveys like the Searching ...
Shubham Kanodia, Arvind F. Gupta, Caleb I. Cañas, Lia Marta Bernabò, Varghese Reji, Te Han, Madison Brady, Andreas Seifahrt, William D. Cochran, Nidia Morrell, Ritvik Basant, Jacob Bean, Chad F. Bender, Zoë L. de Beurs, Allyson Bieryla, Alexina Birkholz, Nina Brown, Franklin Chapman, David R. Ciardi, Catherine A. Clark, Ethan G. Cotter, Scott A. Diddams, Samuel Halverson, Suzanne Hawley, Leslie Hebb, Rae Holcomb, Steve B. Howell, Henry A. Kobulnicky, Adam F. Kowalski, Alexander Larsen, Jessica Libby-Roberts, Andrea S. J. Lin, Michael B. Lund, Rafael Luque, Andrew Monson, Joe P. Ninan, Brock A. Parker, Nishka Patel, Michael Rodruck, Gabrielle Ross, Arpita Roy, Christian Schwab, Guđmundur Stefánsson, Aubrie Thoms, Andrew Vanderburg   +44 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Double-edged Sword: The Influence of Tidal Interaction on Stellar Activity in Binaries

The Astrophysical Journal
Using the LAMOST DR7 low-resolution spectra, we carried out a systematic study of stellar chromospheric activity in both single and binary stars. We constructed a binary sample and a single-star sample, mainly using the binary belt and the main sequence ...
Yuedan Ding, Shidi Zhang, Henggeng Han, Wenyuan Cui, Song Wang, Min Fang, Yawei Gao   +6 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Exoplanet Aeronomy: A Case Study of WASP-69 b’s Variable Thermosphere

The Astronomical Journal
Aeronomy, the study of Earth’s upper atmosphere and its interaction with the local space environment, has long traced changes in the thermospheres of Earth and other solar system planets to solar variability in the X-ray and extreme-ultraviolet ...
W. Garrett Levine, Shreyas Vissapragada, Adina D. Feinstein, George W. King, Aleck Hernandez, Lía Corrales, Michael Greklek-McKeon, Heather A. Knutson   +7 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

K Dwarf Radius Inflation and a 10 Gyr Spin-down Clock Unveiled through Asteroseismology of HD 219134 from the Keck Planet Finder

The Astrophysical Journal
We present the first asteroseismic analysis of the K3 V planet host HD 219134 based on four consecutive nights of radial velocities collected with the Keck Planet Finder.
Yaguang Li, Daniel Huber, J. M. Joel Ong, Jennifer van Saders, R. R. Costa, Jens Reersted Larsen, Sarbani Basu, Timothy R. Bedding, Fei Dai, Ashley Chontos, Theron W. Carmichael, Daniel Hey, Hans Kjeldsen, Marc Hon, Tiago L. Campante, Mário J. P. F. G. Monteiro, Mia Sloth Lundkvist, Nicholas Saunders, Howard Isaacson, Andrew W. Howard, Steven R. Gibson, Samuel Halverson, Kodi Rider, Arpita Roy, Ashley D. Baker, Jerry Edelstein, Chris Smith, Benjamin J. Fulton, Josh Walawender   +28 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source