Results 41 to 50 of about 42,939 (197)

Statistics and Habitability of F-type Star–Planet Systems

The Astrophysical Journal Supplement Series
F-type star–planet systems represent an intriguing case for habitability studies. Although F-type stars spend considerably less time on the main sequence (MS) than G-, K-, and M-type stars, they still offer a unique set of features, allowing for the ...
Shaan D. Patel, Manfred Cuntz, Nevin N. Weinberg   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Demography of Stellar Radio Population within 500 pc: A VLASS-Gaia DR3 Study

The Astronomical Journal
In this work, we have carried out a systematic analysis of the Very Large Array Sky Survey (VLASS) quick look catalogs together with Gaia DR3 to identify the optical counterparts of 3 GHz radio emitters within 500 pc to obtain a homogeneous statistical ...
D. Ayanabha, Mayank Narang, Manoj Puravankara, B. Shridharan, H. Tyagi, Bihan Banerjee, Prasanta K. Nayak, Arun Surya   +7 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Ultraviolet and Chromospheric Activity and Habitability of M Stars

The Astrophysical Journal
M-type stars are crucial for stellar activity studies because they cover two types of magnetic dynamos and are particularly intriguing for habitability studies due to their abundance and long lifespans during the main-sequence stage.
Xue Li, Song Wang, Henggeng Han, Huiqin Yang, Chuanjie Zheng, Yang Huang, Jifeng Liu   +6 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Host-star Properties of Hot, Warm, and Cold Jupiters in the Solar Neighborhood from Gaia Data Release 3: Clues to Formation Pathways

The Astronomical Journal
Giant planets exhibit diverse orbital properties, hinting at their distinct formation and dynamic histories. In this paper, using Gaia Data Release 3 (DR3), we investigate if and how the orbital properties of Jupiters are linked to their host star ...
Bihan Banerjee, Mayank Narang, P. Manoj, Thomas Henning, Himanshu Tyagi, Arun Surya, Prasanta K. Nayak, Mihir Tripathi   +7 more
doaj   +1 more source

Unveiling the Variability and Chemical Composition of AL Col

Galaxies
In this study, we present analysis of TESS photometry, spectral energy distribution (SED), high-resolution spectroscopy, and spot modeling of the α2 CVn-type star AL Col (HD 46462).
Surath C. Ghosh, Santosh Joshi, Samrat Ghosh, Athul Dileep, Otto Trust, Mrinmoy Sarkar, Jaime Andrés Rosales Guzmán, Nicolás Esteban Castro-Toledo, Oleg Malkov, Harinder P. Singh, Kefeng Tan, Sarabjeet S. Bedi   +11 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source