Results 41 to 50 of about 512,862 (249)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

TIC 290061484: A Triply Eclipsing Triple System with the Shortest Known Outer Period of 24.5 Days

The Astrophysical Journal
We have discovered a triply eclipsing triple-star system, TIC 290061484, with the shortest known outer period, P _out , of only 24.5 days. This “eclipses” the previous record set by λ Tauri at 33.02 days, which held for 68 yr.
V. B. Kostov, S. A. Rappaport, T. Borkovits, B. P. Powell, R. Gagliano, M. Omohundro, I. B. Bíró, M. Moe, S. B. Howell, T. Mitnyan, C. A. Clark, M. H. Kristiansen, I. A. Terentev, H. M. Schwengeler, A. Pál, A. Vanderburg   +15 more
doaj   +1 more source

Star formation environments and the distribution of binary separations [PDF]

, 1998
We have carried out K-band speckle observations of a sample of 114 X-ray selected weak-line T Tauri stars in the nearby Scorpius-Centaurus OB association. We find that for binary T Tauri stars closely associated to the early type stars in Upper Scorpius,
Brandner W., Brandner W., de Geus E. J., Duquennoy A., Durisen R. H., Kohler R., Neuhauser R., Rainer Köhler, Reipurth B., Wolfgang Brandner   +9 more
core   +2 more sources

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

A New Asteroseismic Kepler Benchmark Constrains the Onset of Weakened Magnetic Braking in Mature Sun-like Stars

The Astrophysical Journal
Stellar spin down is a critical yet poorly understood component of stellar evolution. In particular, results from the Kepler Mission imply that mature age, solar-type stars have inefficient magnetic braking, resulting in a stalled spin-down rate. However,
Vanshree Bhalotia, Daniel Huber, Jennifer L. van Saders, Travis S. Metcalfe, Keivan G. Stassun, Timothy R. White, Víctor Aguirre Børsen-Koch, Warrick H. Ball, Sarbani Basu, Aldo M. Serenelli, Erica Sawczynec, Joyce A. Guzik, Andrew W. Howard, Howard Isaacson   +13 more
doaj   +1 more source

Age dependence of wind properties for solar type stars: a 3d study [PDF]

, 2016
Young and rapidly rotating stars are known for intense, dynamo generated magnetic fields. Spectropolarimetric observations of those stars in precisely aged clusters are key input for gyrochronology and magnetochronology. We use ZDI maps of several young K-type stars of similar mass and radius but with various ages and rotational periods, to perform 3D ...
arxiv   +1 more source

Regular frequency patterns in the young delta Scuti star HD 261711 observed by the CoRoT and MOST satellites [PDF]

, 2013
We concentrate on an asteroseismological study of HD 261711, a rather hot delta Scuti type pulsating member of the young open cluster NGC 2264 located at the blue border of the instability region.
Auvergne, M., Baglin, A., Barnes, T. G., Bohlender, D., Chaintreuil, S., Fossati, L., Guenther, D. B., Kuschnig, R., Matthews, J. M., Moffat, A. F. J., Rowe, J. F., Rucinski, S. M., Ryabchikova, T., Sasselov, D., Themessl, N., Weiss, W. W., Zwintz, K.   +16 more
core   +3 more sources

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, EarlyView.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Hot Stars in the GALEX Ultraviolet Sky Surveys (GUVcat_AISxSDSS_HS) and the Binary Fraction of Hot Evolved Stars

The Astrophysical Journal Supplement Series
We present a catalog of 71,364 pointlike UV sources with Sloan Digital Sky Survey (SDSS) photometry and GALEX far-UV (FUV)−near-UV (NUV) ≤0.1 mag.
Luciana Bianchi
doaj   +1 more source

The [2Fe‐2S] cluster of mitochondrial outer membrane protein mitoNEET has an O2‐regulated nitric oxide access tunnel

FEBS Letters, EarlyView.
The mitochondrial outer membrane iron–sulphur ([Fe‐S]) protein mitoNEET is a target of the type‐2 diabetes drug pioglitazone. Its unknown molecular function is linked to respiratory complex activity and mitochondrial function. We discovered that O2 protects the mitoNEET [2Fe‐2S] cluster against NO oxidation and desensitization towards reduction by H2S.
Thao Nghi Hoang, Meritxell Wu‐Lu, Alberto Collauto, Peter‐Leon Hagedoorn, Madalina Alexandru, Maike Henschel, Shahram Kordasti, Maria Andrea Mroginski, Maxie M. Roessler, Kourosh H. Ebrahimi   +9 more
wiley   +1 more source