Results 71 to 80 of about 512,862 (249)

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Demography of Stellar Radio Population within 500 pc: A VLASS-Gaia DR3 Study

open access: yesThe Astronomical Journal
In this work, we have carried out a systematic analysis of the Very Large Array Sky Survey (VLASS) quick look catalogs together with Gaia DR3 to identify the optical counterparts of 3 GHz radio emitters within 500 pc to obtain a homogeneous statistical ...
D. Ayanabha   +7 more
doaj   +1 more source

VLT optical observations of V821 Ara(=GX339-4) in an extended "off" state [PDF]

open access: yes, 2001
We report on low-resolution spectroscopy of GX339-4 during its current, extended X-ray `off' state in May 2000 (r=20.1) obtained with the VLT Focal Reducer/low dispersion Spectrograph (FORS1). Although we do not positively detect the secondary star in GX339-4 we place an upper limit of 30 percent on the contribution of a ``normal'' K-type secondary ...
arxiv   +1 more source

Optical BVRI Photometry of Common Proper Motion F/G/K+M Wide Separation Binaries [PDF]

open access: yes, 2014
We present optical (BVRI) photometric measurements of a sample of 76 common proper motion wide separation main sequence binary pairs. The pairs are composed of a F-, G-, or K-type primary star and an M-type secondary.
Chavez, Joy   +4 more
core   +3 more sources

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

X-ray Emission from Young Stellar Objects in the \epsilon Chamaeleontis Group: the Herbig Ae Star HD 104237 and Associated Low-Mass Stars

open access: yes, 2008
We present Chandra-HETGS observations of the Herbig Ae star HD 104237 and the associated young stars comprising lower mass stars, in the 0.15-1.75\msol mass range, in their pre-main sequence phase.
Alcala J. M.   +18 more
core   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Ultraviolet and Chromospheric Activity and Habitability of M Stars

open access: yesThe Astrophysical Journal
M-type stars are crucial for stellar activity studies because they cover two types of magnetic dynamos and are particularly intriguing for habitability studies due to their abundance and long lifespans during the main-sequence stage.
Xue Li   +6 more
doaj   +1 more source

Search for Cold Debris Disks around M-dwarfs [PDF]

open access: yes, 2006
Debris disks are believed to be related to planetesimals left over around stars after planet formation has ceased. The frequency of debris disks around M-dwarfs which account for 70% of the stars in the Galaxy is unknown while constrains have already been found for A- to K-type stars.
arxiv   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

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