Results 81 to 90 of about 388,482 (233)
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé+7 more
wiley +1 more source
Fe I and Fe II Abundances of Solar-Type Dwarfs in the Pleiades Open Cluster [PDF]
We have derived Fe abundances of 16 solar-type Pleiades dwarfs by means of an equivalent width analysis of Fe I and Fe II lines in high-resolution spectra obtained with the Hobby - Eberly Telescope and High Resolution Spectrograph.
Adele L. Plunkett+7 more
core +4 more sources
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak+14 more
wiley +1 more source
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka+10 more
wiley +1 more source
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu+15 more
wiley +1 more source
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair+17 more
wiley +1 more source
Stellar activity cycles in a model for magnetic flux generation and transport
We present results from a model for magnetic flux generation and transport in cool stars and a qualitative comparison of models with observations. The method combines an alpha-omega dynamo at the base of the convection zone, buoyant rise of magnetic flux
Emre Işik+6 more
core +1 more source
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes+20 more
wiley +1 more source
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser+11 more
wiley +1 more source
WISE J080822.18-644357.3 - a 45 Myr-old accreting M dwarf hosting a primordial disc
WISE J080822.18$-$644357.3 was recently identified as a new M dwarf debris disc system and a candidate member of the 45 Myr-old Carina association. Given that the strength of its infrared excess ($L_{\rm IR}/L_{\rm \star}\simeq 0.1$) appears to be more ...
Bell, Cameron P. M.+2 more
core +1 more source