Results 51 to 60 of about 2,975,063 (124)

A Critical Method for the Evaluation of Evidence: François Gorphe’s (1889-1959) Contribution to a Science of Proof à la française

open access: yesQuaestio Facti, 2021
In his 1924 book La critique du témoignage, the French judge François Gorphe (1889-1959) advocated the need that evaluation of evidence be based on the best scientific knowledge available.
Olivier Leclerc
doaj   +1 more source

Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence. [PDF]

open access: yes, 2016
The two-component system PhoP-PhoQ is highly conserved in bacteria and regulates virulence in response to various signals for bacteria within the mammalian host.
Shuting Liu (500724)   +21 more
core   +1 more source

Miguel Baraona Cockerell: The Plot and the Threads. Capitalist Modernization and the Four Spirals of Modernity. EUNA 2016

open access: yesRevista Latinoamericana de Derechos Humanos, 2017
This paper develops the line of thought of Miguel Baraona Cockerell, present in his book The Plot and the Threads. Capitalist Modernization and the Four Spirals of Modernity. In this book, he broadly argues that globalization, modernization, conflict and
Lucía Rincón Soto
doaj   +1 more source

A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201

open access: yes, 2009
Aims Our objective was to explore the functional interdependence of protein kinase A (PKA) phosphorylation with binding of modulatory FK506 binding proteins (FKBP12/12.6) to the ryanodine receptor (RyR).
Blayney, Lynda Mary   +3 more
core   +1 more source

心室細動とその抑制機序に関する実験的検討 : ベンゾチアゼピン誘導体K201とジルチアゼムの比較検討 [PDF]

open access: yes
Ca^負荷下イソプロテレノール誘発心室細動(Iso-Vf)および虚血再灌流誘発心室細動(Rep-Vf)に対するベンゾチアゼピン誘導体K201およびジルチアゼムの抑制効果を検討した. Wistar雄性ラットを用い,Ca^負荷(12mg/kg/min) 20分間後イソプロテレノール(0.6μg/kg/分)を20分間投与した.虚血再灌流実験では左冠動脈前下行枝を結紮5分後再灌流した.
大谷, 直由   +1 more
core   +1 more source

Justicia transicional y predictores del perdón político en Chile

open access: yesRevista Latinoamericana de Derechos Humanos, 2015
Se estudia el rol predictor de variables psicosociales sobre las creencias en torno al perdón político luego de la dictadura chilena (N=1267). Un análisis de regresión múltiple indica que las variables que cumplen un rol más relevante (R2=0.23) son: la ...
Maitane Arnoso Martinez   +2 more
doaj   +1 more source

A Novel Cardioprotective Drug, K201 (JTV519), Induces Prolongation of QT and QTc Intervals, but not Torsades de Pointes [PDF]

open access: yes
K201 (JTV-519; 4-[-3{1-(4-benzyl) piperidinyl} propionyl]-7-methoxy-2, 3, 4, 5-tetrahydro-1, 4-ben-zothiazepine), is a multi-channel blocker and a ryanodine receptor stabilizer that exhibits strong cardiopro-tective and antiarrhythmic effects.
Matsuda, Toshiya   +4 more
core   +1 more source

Additional file 1: of Multiple morphogenic culture systems cause loss of resistance to cassava mosaic disease

open access: yes, 2018
Figure S1. Response of organogenesis-derived plants of cassava to inoculation with an infectious geminivirus clone of EACMV-K201 and MeSPY1–VIGS. a EACMV-K201 (left) and MeSPY1-VIGS (right) challenged plants of micropropagated TME 7.
Raj Chauhan (5449343)   +2 more
core   +1 more source

Designing New Drugs to Treat Cardiac Arrhythmia [PDF]

open access: yes, 2012
Heart failure resulting from different forms of cardiomyopathy is defined as the inability of the heart to pump sufficient blood to meet the body\u27s metabolic demands.
Ye, Yanping
core   +1 more source

左室拡張障害の発生とその予防に関する実験的検討 : ラット陳旧性梗塞心による検討 [PDF]

open access: yes
陳旧性心筋梗塞ラットで,ノルエピネフリン誘発性拡張障害を惹起させ,その発生様式ならびにリアノジン受容体安定化作用を有する1,4-ベンゾチアゼピン誘導体K201の改善作用を調べた.冠動脈結紮10〜13週間後,ノルエピネフリン(20 mg/kg/分)を30分間投与し,K201 投与群(n=5),非投与群(n=5),sham群(n=3)で,心拍数,左室収縮期圧,左室拡張期最小圧,左室拡張末期圧,+dP/dt,-dP/dtを測定した.K201(0.1 mg/kg/分 ...
ニシノ, セツ, 西野, 節
core   +1 more source

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