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Docking of inhibitors to the structure of the human K‐Cl cotransporter
The FASEB Journal, 2020Following the release of the cryo‐electron microscopy structure of the human K‐Cl cotransporter, hKCC1, we used a ligand‐protein docking program (Autodock Vina from the Scripps Research Institute) to assess the binding of KCC inhibitors to the K‐Cl cotransporter.
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Characteristics and functions of Na-K-Cl cotransport in epithelial tissues
American Journal of Physiology-Cell Physiology, 1987This review summarizes our present understanding of Na-K-Cl cotransport and its physiological role in absorption and secretion of electrolytes and water in epithelial tissues. In the past several years an extensive literature about this cotransporter has developed due to its widespread distribution in a variety of cell types and its essential role in ...
H. C. Palfrey +2 more
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Immunocytochemical studies of the Na-K-Cl cotransporter of shark kidney
American Journal of Physiology-Renal Physiology, 1996The Na-K-Cl cotransporter (NKCC or BSC) has been described in numerous secretory and reabsorptive epithelia and is an important part of the mechanism of NaCl reabsorption in both the mammalian and elasmobranch kidneys. We have recently developed a panel of four monoclonal antibodies (MAbs) raised to the 195-kDa Na-K-Cl cotransport protein of the shark
John A. Payne +3 more
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Molecular Properties of the Na-K-Cl-Cotransporter
1991Since 1980, when the transporter was first characterized in Ehrlich Ascites tumor cells [1], the Na-K-Cl cotransport system has been found to play a major role in volume regulation in cells in general, and in transepithelial active chloride transport in epithelia in particular [2].
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The Na‐K‐Cl Cotransporter in the Kidneya
Annals of the New York Academy of Sciences, 1989openaire +3 more sources
Hypertension in K-Cl Cotransporter-3 Knockout Mice
2006Adragna, N C +4 more
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The K + -Cl − Cotransporter KCC2 and Zolpidem
2016Masahiro Shibasaki +2 more
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Structure and function of the neuron-specific K-Cl cotransporter
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000P.M Cala +3 more
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Expression of K+/Cl- cotransporters (KCC) in vestibular compensation.
2006Mohammad Reza, Ardehali +4 more
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