Results 41 to 50 of about 352,958 (260)

Cation-Chloride Cotransporters, Na/K Pump, and Channels in Cell Water and Ion Regulation: In silico and Experimental Studies of the U937 Cells Under Stopping the Pump and During Regulatory Volume Decrease

Frontiers in Cell and Developmental Biology, 2021
Cation-coupled chloride cotransporters play a key role in generating the Cl– electrochemical gradient on the cell membrane, which is important for regulation of many cellular processes.
Valentina E. Yurinskaya, Alexey A. Vereninov   +1 more
doaj   +1 more source

Imbalanced expression of cation-chloride cotransporters as a potential therapeutic target in an Angelman syndrome mouse model

Scientific Reports, 2023
Angelman syndrome is a neurodevelopmental disorder caused by loss of function of the maternally expressed UBE3A gene. Treatments for the main manifestations, including cognitive dysfunction or epilepsy, are still under development.
Kiyoshi Egawa, Miho Watanabe, Hideaki Shiraishi, Daisuke Sato, Yukitoshi Takahashi, Saori Nishio, Atsuo Fukuda   +6 more
doaj   +1 more source

Glial Chloride Homeostasis Under Transient Ischemic Stress

Frontiers in Cellular Neuroscience, 2021
High water permeabilities permit rapid adjustments of glial volume upon changes in external and internal osmolarity, and pathologically altered intracellular chloride concentrations ([Cl–]int) and glial cell swelling are often assumed to represent early ...
Miriam Engels, Manu Kalia, Manu Kalia, Sarah Rahmati, Laura Petersilie, Peter Kovermann, Michel J. A. M. van Putten, Christine R. Rose, Hil G. E. Meijer, Thomas Gensch, Christoph Fahlke   +10 more
doaj   +1 more source

Lacosamide decreases neonatal seizures without increasing apoptosis

Epilepsia, Volume 63, Issue 12, Page 3051-3065, December 2022., 2022
Abstract Objective Many seizing neonates fail to respond to first‐line anticonvulsant medications. Phenobarbital, an allosteric modulator of γ‐aminobutyric acid type A (GABAA) receptors, has low efficacy in treating neonatal seizures and causes neuronal apoptosis. Nonetheless, it is one of the most used anticonvulsants in this age group.
Rachel L. Langton, Shaunik Sharma, Grant C. Tiarks, Alexander G. Bassuk, Joseph Glykys   +4 more
wiley   +1 more source

Balance of Na+, K+, and Cl– Unidirectional Fluxes in Normal and Apoptotic U937 Cells Computed With All Main Types of Cotransporters

Frontiers in Cell and Developmental Biology, 2020
Fluxes of monovalent ions through the multiple pathways of the plasma membrane are highly interdependent, and their assessment by direct measurement is difficult or even impossible.
Valentina E. Yurinskaya, Igor A. Vereninov, Alexey A. Vereninov   +2 more
doaj   +1 more source

Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells

Journal of Pharmacological Sciences, 2017
Intestinal Cl− secretion is involved in the pathogenesis of secretory diarrheas including cholera. We recently demonstrated that flufenamic acid (FFA) suppressed Vibrio cholerae El Tor variant-induced intestinal fluid secretion via mechanisms involving ...
Pawin Pongkorpsakol, Chantapol Yimnual, Varanuj Chatsudthipong, Vatcharin Rukachaisirikul, Chatchai Muanprasat   +4 more
doaj   +1 more source

Phosphorylation and transport in the Na-K-2Cl cotransporters, NKCC1 and NKCC2A, compared in HEK-293 cells. [PDF]

PLoS ONE, 2011
Na-K-2Cl cotransporters help determine cell composition and volume. NKCC1 is widely distributed whilst NKCC2 is only found in the kidney where it plays a vital role reabsorbing 20% of filtered NaCl.
Anke Hannemann, Peter W Flatman
doaj   +1 more source

The electroneutral Na+-(K+)-Cl− cotransport family

Kidney International, 1996
Recently the molecular identification of the major electroneutral sodium-potassium-chloride entry mechanisms present on apical membranes of distal nephron segments of the mammalian kidney, on basolateral membranes of many non-renal epithelial cells and on certain non-epithelial tissues has been achieved. These transporters represent a major pathway for
Gerardo Gamba, M. R. Kaplan, Steven C. Hebert   +2 more
openaire   +3 more sources

Mechanistic insights into the primary and secondary alterations of renal ion and water transport in the distal nephron

Journal of Internal Medicine, Volume 293, Issue 1, Page 4-22, January 2023., 2023
Abstract The kidneys, by equilibrating the outputs to the inputs, are essential for maintaining the constant volume, pH, and electrolyte composition of the internal milieu. Inability to do so, either because of internal kidney dysfunction (primary alteration) or because of some external factors (secondary alteration), leads to pathologies of varying ...
Nahid Tabibzadeh, Gilles Crambert
wiley   +1 more source

AP2S1 regulates APP degradation through late endosome–lysosome fusion in cells and APP/PS1 mice

Traffic, Volume 24, Issue 1, Page 20-33, January 2023., 2023
Fission events at endo‐lyso interface could be favored in the presence of AP2S1, which is reminiscent of membrane fission during endocytosis. In contrast, lack of AP2S1 may inhibit this process, and alternatively facilitate endo‐lyso fusion and content exchange, leading to lysosomal degradation of APP.
Qi‐Xin Wen, Biao Luo, Xiao‐Yong Xie, Gui‐Feng Zhou, Jian Chen, Li Song, Yue Liu, Shi‐Qi Xie, Long Chen, Kun‐Yi Li, Xiao‐Jiao Xiang, Guo‐Jun Chen   +11 more
wiley   +1 more source