Results 41 to 50 of about 6,975 (268)

The electroneutral Na+-(K+)-Cl− cotransport family

Kidney International, 1996
Recently the molecular identification of the major electroneutral sodium-potassium-chloride entry mechanisms present on apical membranes of distal nephron segments of the mammalian kidney, on basolateral membranes of many non-renal epithelial cells and on certain non-epithelial tissues has been achieved. These transporters represent a major pathway for
Hebert, Steven C., Gamba, Gerardo, Kaplan, Mark   +2 more
openaire   +2 more sources

Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis

eLife, 2018
Fast synaptic inhibition in the nervous system depends on the transmembrane flux of Cl- ions based on the neuronal Cl- driving force. Established theories regarding the determinants of Cl- driving force have recently been questioned.
Kira M Düsterwald, Christopher B Currin, Richard J Burman, Colin J Akerman, Alan R Kay, Joseph V Raimondo   +5 more
doaj   +1 more source

Evidence for K‐Cl cotransporter heterodimerization

The FASEB Journal, 2012
In humans, mutations in the gene SLC12A6 which encodes for KCC3 result in an autosomal recessive disease, known as ACCPN (Agenesis of the Corpus Callosum associated with Peripheral Neuropathy). In the present work we focused our efforts in understanding the lethality demonstrated by the homozygosity of the Glu289Gly (E289G ...
Jose Ponce-Coria, Jinlong Ding, Eric Delpire   +2 more
openaire   +1 more source

Regulated phosphorylation of the K-Cl cotransporter KCC3 at dual C-terminal threonines is a potent switch of intracellular potassium content and cell volume homeostasis

Frontiers in Cellular Neuroscience, 2015
The defense of cell volume against excessive shrinkage or swelling is a requirement for cell function and organismal survival. Cell swelling triggers a coordinated homeostatic response termed regulatory volume decrease (RVD), resulting in K+ and Cl ...
Norma C. Adragna, Nagendra Babu Ravilla, Peter K. Lauf, Peter K. Lauf, Gulnaz eBegum, Arjun R. Khanna, Dandan eSun, Dandan eSun, Kristopher T Kahle, Kristopher T Kahle   +9 more
doaj   +1 more source

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]

, 2017
There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas, Fedrowitz, Maren, Hampel, Philip, Kaczmarek, Edith, Löscher, Wolfgang, Römermann, Kerstin, Sweet, Douglas H., Töllner, Kathrin   +7 more
core   +2 more sources

Na-K-Cl Cotransporter Contributes to Glutamate-Mediated Excitotoxicity [PDF]

The Journal of Neuroscience, 2003
We hypothesized that cation-dependent Cl-transport protein Na-K-Cl cotransporter isoform 1 (NKCC1) plays a role in the disruption of ion homeostasis in cerebral ischemia. In the current study, a role for NKCC1 in neuronal death was elucidated in neurotoxicity induced by glutamate and oxygen and glucose deprivation (OGD).
Joe, Beck, Brett, Lenart, Douglas B, Kintner, Dandan, Sun   +3 more
openaire   +2 more sources

Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.

PLoS ONE, 2017
Cation Chloride Cotransporters (CCCs) comprise secondary active membrane proteins mainly mediating the symport of cations (Na+, K+) coupled with chloride (Cl-). They are divided into K+-Cl- outward transporters (KCCs), the Na+-K+-Cl- (NKCCs) and Na+-Cl- (
Anna-Maria Hartmann, Lucie I Pisella, Igor Medina, Hans Gerd Nothwang   +3 more
doaj   +1 more source

A novel delta current method for transport stoichiometry estimation. [PDF]

, 2014
BackgroundThe ion transport stoichiometry (q) of electrogenic transporters is an important determinant of their function. q can be determined by the reversal potential (Erev) if the transporter under study is the only electrogenic transport mechanism or ...
Kao, Liyo, Kurtz, Ira, Shao, Xuesi M
core   +1 more source

Influx of Calcium through L-type Calcium Channels in Early Postnatal Regulation of Chloride Transporters in the Rat Hippocampus [PDF]

, 2009
During the early postnatal period, GABAB receptor activation facilitates L-type calcium current in rat hippocampus. One developmental process that L-type current may regulate is the change in expression of the K+Cl− co-transporter (KCC2) and N+K+2Cl− co ...
Balakrishnan, Ben-Ari, Ben-Ari, Bettler, Bi, Blaesse, Carter, Cherubini, Davies, Delpire, Dutar, Fiumelli, Fujikawa, Galanopoulou, Ganguly, Gähwiler, Harrison, Hübner, Kahle, Kanaka, Kanaumi, Khazipov, Lambert, Leinekugel, Leinekugel, Leinekugel, Liu, Lu, Mynlieff, Newberry, Nuñez, Owens, Payne, Pfrieger, Plotkin, Rissman, Rivera, Scholz, Shen, Siebler, Stein, Takahashi, Thompson, Vicario-Abejón, Wang, Wu, Yan, Yu, Yuste   +48 more
core   +2 more sources

Regulation of K-Cl Cotransport: from Function to Genes [PDF]

Journal of Membrane Biology, 2004
This review intends to summarize the vast literature on K-Cl cotransport (COT) regulation from a functional and genetic viewpoint. Special attention has been given to the signaling pathways involved in the transporter's regulation found in several tissues and cell types, and more specifically, in vascular smooth muscle cells (VSMCs).
N C, Adragna, M, Di Fulvio, P K, Lauf
openaire   +2 more sources