Conceptual Metaphor Theory and Classical Theory: Affinities Rather than Divergences [PDF]
Conceptual Metaphor Theory makes some strong claims against so-called Classical Theory which spans the accounts of metaphors from Aristotle to Davidson.
Mácha, Jakub
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G Protein-Coupled Receptor Signaling: Implications and Therapeutic Development Advances in Cancers. [PDF]
G protein‐coupled receptors (GPCRs) are the dynamic protein family in the human genome. GPCR dysregulation aids in the advancement of cancer through increased migration, survival, and proliferation. Novel treatments that target GPCR signaling include orthosteric ligands, biased receptor mutants, PROTACs, and antibody–drug conjugates.
Khan IR +6 more
europepmc +2 more sources
Paradigms and self-reference: what is the point of asserting paradoxical sentences? [PDF]
A paradox, according to Wittgenstein, is something surprising that is taken out of its context. Thus, one way of dealing with paradoxical sentences is to imagine the missing context of use.
Mácha, Jakub
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Metaphor in Analytic Philosophy and Cognitive Science [PDF]
This article surveys theories of metaphor in analytic philosophy and cognitive science. In particular, it focuses on contemporary semantic, pragmatic and non-cognitivist theories of linguistic metaphor and on the Conceptual Metaphor Theory advanced by ...
Mácha, Jakub
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A Century of Czech Tramping [PDF]
The article describes the history and major characteristics of an independent Czech youth movement called “tramping.” The movement originated in the 1910s-1920s as an unorganized offshoot of boy scouting and E. T.
Pohunek, Jan
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Intrinsic Factors Influencing Simvastatin and Simvastatin Acid Pharmacokinetics: Age-Related Studies in Thai Adults and Cross-Population Comparisons. [PDF]
ABSTRACT Intrinsic factors such as age and ethnicity influence statin pharmacokinetics (PK) and may increase the risk of muscle‐related adverse events. This study investigated the effect of age on the PK of simvastatin (SV) and its active metabolite, simvastatin acid (SVA), in healthy Thai subjects using an LC–MS/MS assay while accounting for key ...
Srimatimanon T +11 more
europepmc +2 more sources
Aktuelle Themen und Methoden der Philosophiegeschichtsschreibung (mit Schwerpunkt russische Philosophie des 19. und 20. Jahrhunderts) [PDF]
0. Philosophiegeschichtsschreibung als Konstruktion 1. Neu- und Wiederaneignungen 2. Fokus Religionsphilosophie 3. Bedingungen philosophischen Schreibens zur Sowjetzeit 4. Kulturgeschichte 5.
Merten, Sabine, Uffelmann, Dirk
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Ortografia elitarna czy egalitarna? Romantyczne dylematy [PDF]
Spelling is not just a problem for students, it is also a serious political issue. This especially concerns the time when the standard literary languages are formed.
Stęplewski, Artur
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Romantyzm jako etykietka pseudohistorycznoliteracka (In margine czeskich międzywojennych dyskusji i polemik literackich) [PDF]
The article deals with the specific presence of the term romanticism in the interwar period (1918–1939) in Czechoslovakia. In the introduction, the author stresses the lack of a precise definition of the term as well as two ways of understanding it.
Gwóźdź-Szewczenko, Ilona
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Versification and Authorship Attribution [PDF]
The technique known as contemporary stylometry uses different methods, including machine learning, to discover a poem’s author based on features like the frequencies of words and character n-grams.
Plecháč, Petr, Šeļa, Artjoms
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