Results 261 to 270 of about 48,573 (291)

Desensitization of Kainate Receptors by Kainate, Glutamate and Diastereomers of 4-Methylglutamate

Neuropharmacology, 1997
The potencies of kainate, glutamate and diastereomers of 4-methylglutamate were determined for activation and steady-state desensitization of GluR6 and dorsal root ganglion-type kainate receptors using whole-cell voltage clamp. In HEK293 cells expressing GluR6, all four diastereomers induced desensitizing inward currents at relatively high ...
K A, Jones, T J, Wilding, J E, Huettner, A M, Costa   +3 more
openaire   +2 more sources

Kainate-like neurotoxicity of folates

Nature, 1981
Kainic acid (KA) is one of the most powerful of a group of ‘excitotoxic’ analogues of the putative neurotransmitter glu-tamate (Glu) whose neurotoxicity may involve an excitatory mechanism mediated through glutamergic postsynaptic receptors1–8. The finding9 that neural membranes have specific sites where KA binds quite firmly and that Glu inhibits such
J W, Olney, T A, Fuller, T, de Gubareff
openaire   +2 more sources

Kainate induces apoptosis in neurons

Neuroscience, 1996
Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood. We have previously characterized a model of kainate neurotoxicity using cerebellar granule cell neurons ...
N A, Simonian, R L, Getz, J C, Leveque, C, Konradi, J T, Coyle   +4 more
openaire   +2 more sources

Kainate receptors: knocking out plasticity

Trends in Neurosciences, 2001
There is increasing evidence that kainate receptors contribute to both postsynaptic and presynaptic signaling. Studies of knockout mice have played a pivotal role in defining the functions of kainate receptors, including a recent study that implicates kainate receptors in frequency-dependent facilitation and long-term potentiation of hippocampal mossy ...
openaire   +2 more sources

Kainate receptor pharmacology and physiology

Cellular and Molecular Life Sciences (CMLS), 1999
Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists.
openaire   +2 more sources

Kainate receptors and synaptic transmission

Progress in Neurobiology, 2003
Excitatory glutamatergic transmission involves a variety of different receptor types, each with distinct properties and functions. Physiological studies have identified both post- and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate receptors.
openaire   +2 more sources

Synaptic plasticity of kainate receptors

Biochemical Society Transactions, 2006
Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors.
openaire   +3 more sources

Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation

Nature Neuroscience, 2017
M. Petrovic, Silvia Viana da Silva, J. Clement, L. Vyklický, C. Mulle, Inmaculada M. González‐González, J. Henley   +6 more
semanticscholar   +1 more source

Kainate receptors

NeuroReport, 1995
H. Onoe, K. Sakai
openaire   +1 more source

Rosmarinic acid exerts a neuroprotective effect in the kainate rat model of temporal lobe epilepsy: Underlying mechanisms

Pharmaceutical Biology, 2015
S. Khamse, S. Sadr, M. Roghani, Gholamreza Hasanzadeh, M. Mohammadian   +4 more
semanticscholar   +1 more source